Results 41 to 50 of about 22,511 (192)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Prenatal exposure to antihypertensive medication: A systematic review of neurodevelopmental and educational outcomes

JCPP Advances, EarlyView.
This systematic review investigated the association of prenatal exposure to antihypertensive medication with longer‐term poor neurodevelopmental outcomes by evaluating the findings from existing literature. We undertook a systematic review of previous studies looking specifically at neurodevelopmental outcomes in children.
Shrifah Alkhalaf, Sarjit Singh, Jill P. Pell, Scott M. Nelson, Daniel F. Mackay, Michael Fleming   +5 more
wiley   +1 more source

Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case‐Series and Literature Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Variants in AFG3‐Like Matrix AAA Peptidase, Subunit 2 (AFG3L2) gene are associated with diverse clinical phenotypes. Here, we describe phenotypic findings of two unrelated children with de novo heterozygous variant and one family with inherited heterozygous variant in AFG3L2 gene.
Sangeetha Yoganathan, Laura Tochen, Jacky Ganguly, Sayoni Roy Chowdhury, Haya S AlFaris, Vivek Pai, Andrea LeBlanc‐Millar, Sara Breitbart, Hrishikesh Kumar, Manohar Shroff, Arun Reginald, Grace Yoon, Alfonso Fasano, George M Ibrahim, Carolina Gorodetsky   +14 more
wiley   +1 more source

Effect of Intraoperative Regional Anesthesia on Postoperative Outcomes in Pediatric Cardiac Surgery—A Systematic Review of Randomized Controlled Trials

Pediatric Anesthesia, EarlyView.
ABSTRACT Objective To conduct a meta‐analysis of postoperative outcomes following the use of regional anesthesia in pediatric cardiac surgery. Data Sources We searched PubMed (MEDLINE), Web of Science, CINAHL, CENTRAL, and Scopus in December 2024 (PROSPERO: CRD420025635423; registered January 2025).
Katariina Hiisivuori, Heli Salmi, Vesa K. Kontinen, Ilari Kuitunen   +3 more
wiley   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Factors Associated With Non‐Vasomotor Menopause Symptoms Experienced by 7285 Women: A UK‐Wide National Survey

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the factors associated with non‐vasomotor menopause symptoms among women in the UK, focusing on the perceived importance of specific symptoms and their association with demographic and treatment‐related factors. Design A cross‐sectional online survey.
Rhianna Davies, Ashwin Goyal, Zachary Nash, Sarah Hillman, Melanie Davies, Nick Panay, Jane Daniels, Tim Hillard, Bonnie Grant, Paula Briggs, Lynne Robinson, Haitham Hamoda, Channa N. Jayasena   +12 more
wiley   +1 more source

Evaluation of Nalbuphine with that of Clonidine as an Adjuvant to IntraThecal 0.5% Hyperbaric Bupivacaine

National Board of Examinations Journal of Medical Sciences
Background and objectives: This study compares the clinical efficacy of nalbuphine and clonidine as adjuvants to 0.5% hyperbaric bupivacaine for Sub arachnoid block.
Vakkakula Kiran Kumar Reddy, B Manaswini, B Anusha, Kattamreddy Ananth Rupesh   +3 more
doaj   +1 more source

Analgesic and antisympathetic effects of clonidine in burn patients, a randomized, double-blind, placebo-controlled clinical trial

Indian Journal of Plastic Surgery, 2007
Objectives:Unlike most other Analgesic drugs, α2 adrenoceptor agonists are capable of producing analgesia. The aim of this study was to evaluate the Analgesic and antisympathetic effects of clonidine, an α2 adrenoceptor agonist in burn patients.Materials
Ostadalipour Abbas, Jamshidi Mojgan, Zamani Alieh, Jamshidi Maryam, Ashrafi Tavasoli Ahmad   +4 more
doaj   +1 more source

Intraoperative clonidine vs lidocaine on hemodynamic response to laryngoscopic intubation and immune function in gynecological surgeries

Ain Shams Journal of Anesthesiology, 2020
Background This prospective randomised double-blind study was carried out on forty patients American Society of Anesthesiologists (ASA) physical status I–II , aged 40–60 years, scheduled for elective abdominal gynecological surgeries under general ...
Sawsan Gaber Mohamed, Noha Mahmoud Hamdy, Amira Abo Elnasr Awad   +2 more
doaj   +1 more source

Effects of intravenous clonidine or dexmedetomidine on haemodynamic responses to laryngoscopy and endotracheal intubation and sedation: A randomised double-blind clinical efficacy study

Journal of Clinical and Scientific Research, 2020
Background: Laryngoscopy and tracheal intubation (LTI) is associated with undesirable haemodynamic (HD) responses. Both clonidine and dexmedetomidine have been tried to attenuate this HD response.
Aloka Samantaray, Mangu Hanumantha Rao, R Naga Divya, Shameem Sunkesula   +3 more
doaj   +1 more source