Results 51 to 60 of about 21,005 (156)

Ex vivo and in silico evaluations of (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid as a β3-adrenoreceptor agonist exerting anti-obesity, anti-inflammatory and hepatoprotective effects on Zucker rats.

PLoS ONE
Obesity increases oxidative stress and inflammation and thereby promotes liver damage and metabolic disorders, such as type 2 diabetes. Although exist anti-obesity treatments with employing anorexic drugs, antioxidants, and β3-adrenergic receptor (β3-ADR)
Laura Cristina Cabrera-Pérez, Itzia Irene Padilla-Martínez, Ángel Miliar-García, Modesto Gómez-López, Marina Olivia Franco-Hernández, Jessica Elena Mendieta-Wejebe, Martha Cecilia Rosales-Hernández   +6 more
doaj   +1 more source

Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment [PDF]

Клиническая офтальмология, 2019
The article reviews historical aspects of direct and indirect (by reducing intraocular pressure (IOP)) neuroprotective effect of brimonidine in terms of modern views on glaucoma monitoring and treatment.
V.P. Erichev, S.Yu. Petrov, A.V. Volzhanin, D.M. Safonova, T.V. Yaremenko, S.A. Kazaryan   +5 more
doaj  

Dexmedetomidine as an Adjuvant in Peripheral Nerve Block

Drug Design, Development and Therapy, 2023
Zheping Chen, Zhenzhen Liu, Chang Feng, Yanwu Jin, Xin Zhao Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic of ChinaCorrespondence: Yanwu Jin; Xin Zhao, Email ...
Chen Z, Liu Z, Feng C, Jin Y, Zhao X
doaj  

Relative and bedside nurse assessment of comfort and communication during propofol, dexmedetomidine, or clonidine-based sedation: pre-planned analysis within the A2B RCT

Health Technology Assessment
Background Optimising comfort and ability to communicate for mechanically ventilated intensive care unit patients is a priority for clinicians, intensive care unit patients and their relatives. Current usual care is propofol-based sedation plus an opioid
Timothy S Walsh, Richard A Parker, Leanne M Aitken, Cathrine A McKenzie, Robert Glen, Christopher J Weir,   +6 more
doaj   +1 more source

Effects of Adrenergic α2-Receptor Agonists on Urinary Bladder Contraction in Conscious Rats

Japanese Journal of Pharmacology, 2000
We investigated the effects of the adrenergic alpha2-receptor agonists clonidine, oxymetazoline and tizanidine on bladder contractions induced by infusing fluid into the bladders of conscious male rats. I.v. clonidine and oxymetazoline (both 0.01 to 0.1 mg/kg) caused bladder hyperactivity, expressed by shortening of the intercontraction interval ...
Kontani, Hitoshi, Tsuji, Toshitsugu, Kimura, Satoko   +2 more
openaire   +3 more sources

Protective Effects of Dexmedetomidine and Amifostine Against Radiotherapy-Induced Kidney Injury

Life
Backgrounds: Approximately 18 million individuals were diagnosed with cancer in 2018. The rate is predicted to exceed 22 million by 2030. Radiotherapy is an essential part of cancer therapy, with well documented local and systemic side effects, including
Sule Batcik, Levent Tumkaya, Eyup Dil, Leyla Kazancioglu, Elif Gaygusuz, Zihni Acar Yazici, Zulkar Ozden, Kagan Kilinc, Tolga Mercantepe   +8 more
doaj   +1 more source

The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study

Drug Design, Development and Therapy
Gaofei Fan, Mingming Han, Shudong Wang, Min Zhang, Fang Kang, Juan Li Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s ...
Fan G, Han M, Wang S, Zhang M, Kang F, Li J   +5 more
doaj  

Controlled Resistant Hypertension Following A Successful Renal Artery Stenting: A Rare Case Report in A Developing Country

Majalah Kardiologi Indonesia
Background Renal artery stenosis is among the etiologies of secondary hypertension in which the diagnosis and therapy are difficult. We report a case of a patient with uncontrollable hypertension with frequent episodes of malignant hypertension ...
Fatihatul Firdaus Munita, Badai Bhatara Tiksnadi, Januar Wibawa Martha, Margareta Ginanti Ratna   +3 more
doaj   +1 more source

Comparative evaluation of intrathecal dexmedetomidine and fentanyl in patients undergoing lower-limb surgery under spinal anesthesia

Asian Journal of Medical Sciences
Background: Different adjuvants have been studied to enhance the quality and extend the duration of spinal anesthesia. The use of dexmedetomidine has been increased in recent times due to its analgesic and sedative properties.
Gurcharan Singh, Amit Kumar , Pulkit Sharma , Nidhi Kumari , Neha Sinha , Muskan   +5 more
doaj   +1 more source

Effects of single and combination dosage regimens of ketorolac and dexmedetomidine on allodynia and nociception in rat model of osteoarthritis: an animal multi-group trial

BMC Anesthesiology
Introduction Ketorolac is a non-steroidal anti-inflammatory drug (NSAID), commonly used for acute pain relief. Dexmedetomidine is a highly selective alpha-2-adrenergic receptor agonists with an analgesic effect.
Saeed Mohammad Taheri, Mona Khoramjouy, Noushin Nikray, Narjes Mohammadzadeh, Sona Eslampour, Ehsan Firoozi, Sepehr Roozdar, Seyed Mohammadreza Hashemian, Mehrdad Faizi   +8 more
doaj   +1 more source