Results 71 to 80 of about 20,695 (270)

Baroreflex mechanisms buffering alpha-adrenergic agonists in conscious dogs

, 1987
To determine the relative importance of the mechanisms utilized by the arterial baroreflex in buffering the pressor and vasoconstrictor responses to alpha-adrenergic receptor agonists, we studied responses to norepinephrine and phenylephrine in ...
S. F. Vatner, A. M. Fujii
core   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

The Effect of Dexmedetomidine on the Acute Pain After Cardiothoracic Surgeries: A Systematic Review

Brazilian Journal of Cardiovascular Surgery
Introduction: Acute post-operative pain remains a troublesome complication of cardiothoracic surgeries. Several randomized controlled trials have examined the efficacy of dexmedetomidine as a single or as an adjuvant agent before, during and after ...
Valiollah Habibi, Farshad Hasanzadeh Kiabi, Hassan Sharifi   +2 more
doaj   +1 more source

AGRN‐, LRP4‐, MUSK‐Related CMS: Clinical, Neurophysiological, Morphological, Genetic and Pathological Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT Congenital myasthenic syndromes (CMS) are inherited disorders caused by mutations in genes encoding proteins essential for neuromuscular junction (NMJ) function. Pathogenic variants have been identified in more than 35 genes, underscoring the complexity of synaptic biology and the wide range of mechanisms that can compromise neuromuscular ...
Rocio‐Nur Villar‐Quiles, Damien Sternberg, Marie‐Christine Nougues, Arnaud Isapof, Bruno Eymard, Stéphanie Bauché   +5 more
wiley   +1 more source

Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

Health Technology Assessment, 2016
Background: Care of critically ill patients in intensive care units (ICUs) often requires potentially invasive or uncomfortable procedures, such as mechanical ventilation (MV). Sedation can alleviate pain and discomfort, provide protection from stressful
Moira Cruickshank, Lorna Henderson, Graeme MacLennan, Cynthia Fraser, Marion Campbell, Bronagh Blackwood, Anthony Gordon, Miriam Brazzelli   +7 more
doaj   +1 more source

Effects of Adrenergic α2-Receptor Agonists on Urinary Bladder Contraction in Conscious Rats

Japanese Journal of Pharmacology, 2000
We investigated the effects of the adrenergic alpha2-receptor agonists clonidine, oxymetazoline and tizanidine on bladder contractions induced by infusing fluid into the bladders of conscious male rats. I.v. clonidine and oxymetazoline (both 0.01 to 0.1 mg/kg) caused bladder hyperactivity, expressed by shortening of the intercontraction interval ...
Kontani, Hitoshi, Tsuji, Toshitsugu, Kimura, Satoko   +2 more
openaire   +3 more sources

Efeitos do bloqueio de receptores a1 do núcleo mediano da rafe sobre o comportamento alimentar e expressão da proteína Fos [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Florianópolis, 2014A serotonina (5HT) é um neurotransmissor envolvido no controle da ingestão de ...
Silva, Eduardo Simão da
core  

Presynaptic Congenital Myasthenic Syndromes

Muscle &Nerve, EarlyView.
ABSTRACT Presynaptic congenital myasthenic syndromes (CMS) encompass a large number of rare neurologic disorders caused by impaired release of acetylcholine (ACh) from motor nerve terminals. There are two main groups of presynaptic CMS: one in which the amount of ACh in synaptic vesicles (SV) is diminished and another in which the mechanism of synaptic
Ricardo A. Maselli
wiley   +1 more source

Study of the selectivity of alpha(1)-adrenergic antagonists by molecular modeling of alpha(1a)-, alpha(1b)-, and alpha(1d)-adrenergic receptor subtypes and docking simulations

, 2013
Modeling of alpha(1a), alpha(1b), and alpha(1d) adrenergic receptor subtypes has been performed using InsightII software and bovine rhodopsin as a template.
Agbaba, Danica, Eric, Slavica, Zloh, Mire, Solmajer, Tom, Kotnik, Miha   +4 more
core   +2 more sources

Ex vivo and in silico evaluations of (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid as a β3-adrenoreceptor agonist exerting anti-obesity, anti-inflammatory and hepatoprotective effects on Zucker rats.

PLoS ONE
Obesity increases oxidative stress and inflammation and thereby promotes liver damage and metabolic disorders, such as type 2 diabetes. Although exist anti-obesity treatments with employing anorexic drugs, antioxidants, and β3-adrenergic receptor (β3-ADR)
Laura Cristina Cabrera-Pérez, Itzia Irene Padilla-Martínez, Ángel Miliar-García, Modesto Gómez-López, Marina Olivia Franco-Hernández, Jessica Elena Mendieta-Wejebe, Martha Cecilia Rosales-Hernández   +6 more
doaj   +1 more source