Results 91 to 100 of about 20,601 (250)

Veterinary Pharmaceutical Safety Competencies for New Graduates: Description of an Interprofessional Simulated Learning Activity

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The misuse and abuse of veterinary anesthetic and analgesic agents pose significant public health risks, particularly with the growing presence of ultrapotent opioids and other anesthetics in the illicit drug trade. In response, there is increasing emphasis on incorporating medication safety training into veterinary curricula.
Margene Anderson, Carrie Schroeder, Kristopher M. Schroeder   +2 more
wiley   +1 more source

LB787 CLE-400: A potent alpha-2 adrenergic receptor agonist for the treatment of chronic itch [PDF]

Journal of Investigative Dermatology, 2021
J. Schumann, E. Caspi, O. Goren, E. Kagan   +3 more
openaire   +1 more source

Pharmacokinetics of Orally Administered Clonidine in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Clonidine is an α‐2 agonist shown to be both well tolerated and useful in the treatment of canine fear‐based disorders, although it is perceived to have a short duration of action. Clonidine is available in regular release and extended‐release formulations, but canine pharmacokinetic (PK) and pharmacodynamic (PD) data on any clonidine ...
Kevin Pflaum, Julia Albright, Sherry Cox, Joe Smith   +3 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond

Obesity Reviews, EarlyView.
ABSTRACT Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause–effect relationship between OAO, CVD, and other systemic complications ...
Wael Almahmeed, Juan S. Barajas‐Gamboa, Mohammad Zubaid, Ebaa Al Ozairi, Abdullah Shehab, Khalid Al‐Rasadi, Charbel Abi Khalil, Noor Al Busaidi, Fahad Al Sindi, Zuhier Awan, Tomader Ali, Khaldoon Al‐Humood, Fatheya Al Awadi, Mohammed Al Hadad, Manal Al Kindi, Khalid Al Habib, Khalid Al Waili, Maryam Alsaeed, Adel Tash, Hani Sabbour   +19 more
wiley   +1 more source

Effects of Phenylephrine, Calcium, Acetylcholine and Diazoxide on Isolated Aorta of Preeclamptic Rats

Armaghane Danesh Bimonthly Journal, 2009
ABESTRACT: Introduction & Objective: Preeclampsia, one of the most significant health problems in human pregnancy, is a leading cause of fetal mortality and maternal death. Alteration in vascular response to vasopressors and vasodilators is proposed as a
MS Talebianpoor, H Mirkhani
doaj  

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source