Results 101 to 110 of about 41,601 (289)

Relative and bedside nurse assessment of comfort and communication during propofol, dexmedetomidine, or clonidine-based sedation: pre-planned analysis within the A2B RCT

Health Technology Assessment
Background Optimising comfort and ability to communicate for mechanically ventilated intensive care unit patients is a priority for clinicians, intensive care unit patients and their relatives. Current usual care is propofol-based sedation plus an opioid
Timothy S Walsh, Richard A Parker, Leanne M Aitken, Cathrine A McKenzie, Robert Glen, Christopher J Weir,   +6 more
doaj   +1 more source

Protective Effects of Dexmedetomidine and Amifostine Against Radiotherapy-Induced Kidney Injury

Life
Backgrounds: Approximately 18 million individuals were diagnosed with cancer in 2018. The rate is predicted to exceed 22 million by 2030. Radiotherapy is an essential part of cancer therapy, with well documented local and systemic side effects, including
Sule Batcik, Levent Tumkaya, Eyup Dil, Leyla Kazancioglu, Elif Gaygusuz, Zihni Acar Yazici, Zulkar Ozden, Kagan Kilinc, Tolga Mercantepe   +8 more
doaj   +1 more source

Role of Selective α and β Adrenergic Receptor Mechanisms in Rat Jejunal Longitudinal Muscle Contractility [PDF]

, 2018
Gut motility is modulated by adrenergic mechanisms. The aim of our study was to examine mechanisms of selective adrenergic receptors in rat jejunum. Spontaneous contractile activity of longitudinal muscle strips from rat jejunum was measured in 5-ml ...
Balsiger, Bruno, Haefliger, Simon, Rickenbacher, Andreas, Seiler, Roland, Shaw, Sidney   +4 more
core  

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]

, 2020
The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III, Kim, Soo-Kyung, Mafi, Amirhossein   +2 more
core   +1 more source

Alpha 2 adrenergic receptors mediate increased venous tone following 5‐HT1A‐receptor agonist administration in rats subjected to hypovolemic shock

The FASEB Journal, 2006
Previously, we found that ganglionic blockade prevented the 5‐HT 1A ‐receptor agonist, 8‐OH‐DPAT, from raising venous tone in rats subjected to circulatory shock. Here we tested whether α 2 ‐adrenergic receptors mediate this increase in venous tone ...
Ruslan Tiniakov, Karie Scrogin
openaire   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

A novel octopamine receptor with preferential expression in Drosophila mushroom bodies [PDF]

, 1998
Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative ...
Han, K-A, Millar, NS
core  

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1 mg/kg. [PDF]

, 2015
Yohimbine is a prototypical alpha2-adrenergic receptor antagonist. Due to its relatively high selectivity, yohimbine is often used in experiments whose purpose is to examine the role of these receptors.
DiMicco, Joseph A., Rusyniak, Daniel E., Zaretskaia, Maria V., Zaretsky, Dmitry V.   +3 more
core   +2 more sources