Results 111 to 120 of about 21,005 (156)

Alpha-2 Adrenergic Receptor Agonists are Neuroprotective in Experimental Models of Glaucoma

European Journal of Ophthalmology, 2001
Purpose The glaucomas are characterized by chronic progressive ganglion cell loss over many years. A drug with neuroprotective activity should increase the resistance of retinal ganglion cells (RGC) to chronic stress or injury and therefore enhance survival.
L A, Wheeler, E, Woldemussie
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Different Affinities of α2-Agonists for Imidazoline and α2-Adrenergic Receptors

American Journal of Hypertension, 1989
It has recently been shown that imidazoline alpha 2-adrenergic agonists, such as clonidine and UK 14,304, selectively bind to both alpha 2- and imidazoline receptors in basolateral membranes from rabbit renal proximal tubule. In order to define the relative affinity of three antihypertensive alpha 2-agonists for the two classes of receptors, we ...
I, Coupry, V, Lachaud, R A, Podevin, E, Koenig, A, Parini   +4 more
openaire   +2 more sources

Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis [PDF]

Pharmacology & Therapeutics, 2009
Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 adrenergic receptors (alpha(2)ARs) on both primary afferent terminals and secondary neurons, and their activation mediates substantial inhibitory control over this ...
George Wilcox, Laura S Stone, Carolyn Fairbanks   +2 more
exaly   +3 more sources

Alpha-2 Adrenergic Receptor Agonists

2014
Alpha-2 adrenergic receptor agonists include clonidine, guanfacine, guanabenz, methyldopa, rilmenidine, and moxonidine. These are centrally active antihypertensive drugs.
Esen Özkaya, Kurtuluş Didem Yazganoğlu   +1 more
openaire   +1 more source

p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.

Molecular Pharmacology, 1990
The binding properties of p-[125I]iodoclonidine [( 125I]PIC) to human platelet membranes and the functional characteristics of PIC are reported. [125I]PIC bound rapidly and reversibly to platelet membranes, with a first-order association rate constant (kon) at room temperature of 8.0 +/- 2.7 x 10(6) M-1 sec-1 and a dissociation rate constant (koff) of ...
M A, Gerhardt, S M, Wade, R R, Neubig
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Effects of an Alpha-2 Adrenergic Receptor Agonist in Spinal Rats

1988
It is now several decades that diverse surgical and pharmacological treatments have been employed to prevent and/or ameliorate the sensory motor deficits which ensue an injury to the spinal cord. The restoration of impaired histological and physiologic parameters by compounds which are membrane stabilizers, antiinflammatory, and antioxidant, and which ...
N. E. Naftchi, R. Lehrer, J. A. Sleis
openaire   +1 more source

Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat

Neuroscience, 1995
We have previously shown that norepinephrine can produce hyperalgesia via an alpha 2-adrenergic receptor mechanism. The alpha 2-adrenergic receptor agonist clonidine has, however, also been shown to produce peripheral analgesia. In view of the multiple alpha 2-subtypes currently known (i.e.
S G, Khasar, P G, Green, B, Chou, J D, Levine   +3 more
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[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].

Archives des maladies du coeur et des vaisseaux, 1989
Imidazolines have been proposed as highly selective drugs for alpha 2-adrenergic receptors. However, we have recently showed that the imidazoline ligand 3H-RX 781094 (idazoxan) binds to both alpha 2-receptors and imidazoline guanidinium receptive substance (IGRS) in rabbit renal proximal tubule.
V, Lachaud, I, Coupry, R A, Podevin, E, Koenig, A, Parini   +4 more
openaire   +1 more source

Management of Traumatic Brain Injury Sequelae With Alpha-2 Adrenergic Receptor Agonists

Journal of Head Trauma Rehabilitation
Objective: To describe clinical uses of the class of alpha-2 receptor agonist medications in the treatment of traumatic brain injury sequelae. Clinicians treating patients with traumatic brain injuries (TBI) will often see patients who have been prescribed alpha-2 agonists or may consider initiating use.
Jamie L. Ott, Thomas K. Watanabe
openaire   +2 more sources

Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist.

The Journal of Pharmacology and Experimental Therapeutics, 1982
The alpha-1 and alpha-2 adrenergic effects of cirazoline were evaluated in guinea-pig aorta and field-stimulated guinea-pig ileum, respectively. Cirazoline was found to be a full agonist at alpha-1 receptors having an ED50, dissociation constant (KA) and relative efficacy similar to that of (-)-norepinephrine.
R R, Ruffolo, J E, Waddell
openaire   +2 more sources