British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Intranasal dexmedetomidine for perioperative analgesia in a patient on naltrexone maintenance therapy. [PDF]
Indian J AnaesthRangari A, Singh S, Mittal S, Garg H.
europepmc +1 more source
Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys
Equine Veterinary Journal, Volume 58, Issue 5, Page 1390-1395, September 2026.Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno +6 more
wiley +1 more source
Xylazine Exposure and Association With Early Physiological and Withdrawal Symptoms in People With Opioid Use Disorder. [PDF]
J Addict MedStrickland JC +6 more
europepmc +1 more source
Journal of Anatomy, Volume 249, Issue 3, Page 565-577, September 2026.Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou +6 more
wiley +1 more source
The Comparative Effectiveness of PDE5 Inhibitors and β3 Agonists Versus α-Blockers in Medical Expulsive Therapy for Distal Ureteric Stones: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]
CureusRamanah M +5 more
europepmc +1 more source
Autophagy in MASLD: A Metabolic and Precision Medicine Perspective
Liver International, Volume 46, Issue 9, September 2026.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga +4 more
wiley +1 more source
Adipocyte Browning: A Promising Avenue in Anti-Obesity Therapy. [PDF]
Int J Mol SciBae YA, Cheon HG.
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Clinical Characterization of Glaucoma in 63 Pet Rabbits (Oryctolagus cuniculus) in Japan
Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.ABSTRACT Objective To characterize the signalment and clinical presentation of glaucoma in pet rabbits. Animal Studied Client‐owned pet rabbits (n = 222) referred to an exotic specialty animal hospital for ophthalmic examination between 2007 and 2023.
Kumiko Kato +3 more
wiley +1 more source
Sedative Effects of Dexmedetomidine and Ketamine or Dexmedetomidine and Midazolam on Tear Production, Ocular Perfusion Pressure and Pupil Diameter in Rabbits. [PDF]
Vet Med SciMohammadzadeh M +2 more
europepmc +1 more source