Results 151 to 160 of about 20,695 (270)

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

A Review of Alpha-2 Adrenergic Agents Implicated in Opioid Use Disorder. [PDF]

ACS Chem Neurosci
Hannum A, Spano I, Ofori E.
europepmc   +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism. [PDF]

Stem Cells Transl Med
Chung SW, Yoon JP, Park SJ.
europepmc   +1 more source

ALPHA-2 ADRENERGIC RECEPTOR AGONISTS FOR THE TREATMENT OF CANCER

, 2021
Zhu, Jingjing, Van den Eynde, Benoit
openaire   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Comparative anatomy and metabolic profiles of brown and white adipose tissue in humans. [PDF]

Front Endocrinol (Lausanne)
Villarreal J, Baranova A.
europepmc   +1 more source

Interaction between alpha-adrenergic receptor agonists and antagonists in canine isolated saphenous vein

, 1998
Köpek v. saphena şeritlerinde postsinaptik alfa-adrener-jik reseptör alt-tiplerini saptamak amacıyla yapılan bu in vitro çalışmada alfa-adrenerjik reseptör agonistlerinden fenilefrin (FE), noradrenalin (NA), Idonidin, UK 14304 ve B-HT 933 ve alfa ...
Barışkaner, Hülagü, Doğan, Necdet
core  

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Advances in the Association Between the <i>ADRB2</i> Gene and Bronchial Asthma: Genetic Polymorphisms, Epigenetic Regulation, and Clinical Applications. [PDF]

Curr Issues Mol Biol
Sun X, Li Y, Bao Y.
europepmc   +1 more source