Results 121 to 130 of about 20,601 (250)

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

Systemic α₂-agonist use and lower hazard of glaucoma compared with β-blockers: a cohort study. [PDF]

BMJ Open Ophthalmol
Abboud I, Khudari AZ, Abdelaal A, Almobayed A, Al'Aref SJ, Myers JS, Lee RK, Elhusseiny AM.   +7 more
europepmc   +1 more source

Prior Authorization for Sacral Nerve Stimulation in the Era of WISeR: Evaluation of U.S. Payer Coverage Policies

Neurourology and Urodynamics, Volume 45, Issue 7, Page 1280-1293, September 2026.
ABSTRACT Introduction Sacral nerve stimulation (SNS) is an established therapy for refractory urinary incontinence, yet the 2025 Wasteful and Inappropriate Service Reduction Model (WISeR) designated it as requiring mandatory prior authorization. No analysis has examined how U.S.
Thriaksh Rajan, Andre Revnew, David Sheyn, Adonis Hijaz, Ramy Abou Ghayda   +4 more
wiley   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

Brimonidine Beyond a Single Specialty: Pharmacological Profile, Dermatologic Applications, and Advances in Drug Delivery Systems. [PDF]

Int J Mol Sci
Jóźwiak W, Pietrusiewicz M, Piechota-Urbańska M, Markowicz-Piasecka M.   +3 more
europepmc   +1 more source

Receptor‐Targeted Antiemetic Strategies in Cats: A Systematic Review and Intervention‐Specific Meta‐Analysis

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Maropitant showed the most consistent controlled evidence for reducing emesis incidence in cats under perioperative or induced‐emesis conditions. Ondansetron may be beneficial in timing‐specific settings, whereas metoclopramide evidence remains insufficient for pooled inference. .
Uğur Ersöz, Çağlar Özkalipci
wiley   +1 more source

Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice. [PDF]

Prog Neurobiol
Antonucci S, Caron G, Dikwella N, Krishnamurthy SS, Harster A, Wasicki B, Zarrin H, Tahanis A, Heuvel FO, Danner SM, Ludolph AC, Grycz K, Bączyk M, Zytnicki D, Roselli F.   +14 more
europepmc   +1 more source

Prophylactic interventions to prevent rebound pain after peripheral nerve block in adults: a systematic review and network meta‐analysis of randomised controlled trials

Anaesthesia, Volume 81, Issue 9, Page 1281-1292, September 2026.
Summary Introduction Rebound pain after peripheral nerve block is recognised increasingly as a postoperative complication that may diminish the benefits of regional anaesthesia. We undertook a systematic review and network meta‐analysis to evaluate pharmacological strategies for its prevention.
Narinder Pal Singh, Jeetinder Kaur Makkar, Chelsea Zhang, Anuradha Borle, Preet Mohinder Singh   +4 more
wiley   +1 more source

Prostaglandin analog therapy challenges and innovation in glaucoma therapeutics. [PDF]

Indian J Ophthalmol
Nath M, Alam K, Halder N, Dada T, Thirumurthy V.   +4 more
europepmc   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source