Results 291 to 300 of about 63,586 (320)

Pharmacokinetics and pharmacodynamics of dexmedetomidine

Drug Development and Industrial Pharmacy, 2016
Dexmedetomidine is an alpha-2 adrenoceptor agonist and has been used as a general anesthetic, sedative and analgesic for about 30 years. The aim of this paper is to review the pharmacokinetics and pharmacodynamics of dexmedetomidine, evaluate physiological factors that may affect the pharmacokinetics of dexmedetomidine, and summarize the ...
Kwok, PCL, Dufay, S, Yuen, VMY, LI, A
openaire   +5 more sources

Dexmedetomidine and Cardiac Arrest [PDF]

Anesthesiology, 2004
Patricia A. Thistlethwaite, Esperanza Ingersoll-Weng, Gerard R. Manecke   +2 more
openaire   +3 more sources

Perineural and intravenous dexamethasone and dexmedetomidine: network meta‐analysis of adjunctive effects on supraclavicular brachial plexus block

Anaesthesia, 2020
Both perineural and intravenous dexamethasone and dexmedetomidine are used as local anaesthetic adjuncts to enhance peripheral nerve block characteristics.
Herman Sehmbi, R. Brull, K. R. Ceballos, U. J. Shah, Janet Martin, A. Tobías, K. Solo, F. Abdallah   +7 more
semanticscholar   +1 more source

Dexmedetomidine: new insights

European Journal of Anaesthesiology, 2011
Dexmedetomidine is a potent alpha-2-adrenergic agonist, more selective than clonidine, with widespread actions on the mammalian brain that include sedation, anaesthetic-sparing, analgesia and sympatholytic properties. A large body of recent work supports its favourable profile in improving outcome and long-term brain function in the critically ill. The
Jean Mantz, Sophie Hamada, Julien Josserand   +2 more
openaire   +3 more sources

Perioperative Dexmedetomidine Supplement Decreases Delirium Incidence After Adult Cardiac Surgery: A Randomized, Double-Blind, Controlled Study.

Journal of Cardiothoracic and Vascular Anesthesia, 2020
OBJECTIVE Conflicting data exist on the effect of dexmedetomidine on delirium. For the present study, a randomized trial was performed to investigate the effect of perioperative dexmedetomidine on the rate of postoperative delirium after cardiac surgery.
V. Likhvantsev, G. Landoni, O. Grebenchikov, A. Ovezov, Yuri V. Skripkin, R. Lembo, Dmitry I. Gaevskiy, A. A. Tereshina, A. Yavorovskiy   +8 more
semanticscholar   +1 more source

Dexmedetomidine pharmacokinetics in the obese

European Journal of Clinical Pharmacology, 2015
This study aims to characterize the influence of body weight and composition on the pharmacokinetics of dexmedetomidine.Twenty obese patients and 20 non-obese patients scheduled for elective laparoscopic surgery were given dexmedetomidine infusion schemes. Venous blood samples were taken during and after dexmedetomidine administration.
Cortínez Fernández, Luis Ignacio, Anderson, Brian J., Holford, Nick H. G., Puga, Valentina, De La Fuente, Natalia, Auad, Hernán, Solari Gajardo, Sandra, Allende, Fidel, Ibacache Figueroa, Mauricio Enrique   +8 more
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Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials

Intensive Care Medicine, 2022
Kimberley A Lewis, F. Alshamsi, K. Carayannopoulos, A. Granholm, Joshua Piticaru, Z. Al Duhailib, D. Chaudhuri, Laura Spatafora, Yuhong Yuan, J. Centofanti, J. Spence, B. Rochwerg, D. Perri, D. Needham, A. Holbrook, J. Devlin, O. Nishida, K. Honarmand, B. Ergan, Eugenia Khorochkov, P. Pandharipande, Mohammed S Alshahrani, T. Karachi, M. Soth, Y. Shehabi, M. Møller, W. Alhazzani   +26 more
semanticscholar   +1 more source

Dexmedetomidine and neuroprotection

Seminars in Anesthesia, Perioperative Medicine and Pain, 2006
Dexmedetomidine is an α-2 adrenoreceptor agonist which has displayed neuroprotective properties in a variety of in vitro and in vivo laboratory studies; however, the mechanism of neuroprotection remains unclear. Modulation of pathways leading to excitatory cell death and apoptosis are likely to be involved, although there is evidence for and against ...
Satwant K. Samra, Ellen Janke
openaire   +2 more sources

Dexmedetomidine for Neurological Surgery

Operative Neurosurgery, 2005
Dexmedetomidine is a new intravenous drug gaining popularity in neuroanesthesia and neurocritical care practice. This alpha2-adrenergic receptor agonist offers a unique "cooperative sedation," anxiolysis, and analgesia with no respiratory depression.
Alex Bekker, Mary K. Sturaitis
openaire   +3 more sources

Whither dexmedetomidine?

Pediatric Anesthesia, 2015
Dexmedetomidine has established a firm position in the armamentarium of anesthesia pharmacology. However, it is still a relatively new drug and its application is based on early evidence that is intriguing but far from conclusive. Based on experience with previous cure-alls, anesthesia clinicians and researchers must insist on more information and ...
Joseph, Cravero, Brian, Anderson, Andrew, Wolf   +2 more
openaire   +2 more sources