Results 211 to 220 of about 95,310 (311)

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Harnessing Methyltransferase‐Guided Targeting for Sequence‐Specific Proximity Labeling of DNA

Angewandte Chemie, EarlyView.
A novel methyltransferase‐mediated approach leveraging rationally designed S‐adenosyl‐L‐methionine (SAM) analogues was developed to achieve sequence‐specific DNA labeling but in proximity to the natural transfer site, addressing key limitations of previously established methods, including ligand instability and methylation‐sensitive labeling.
Xiong Chen, Gang Wen, Niels Ooghe, Sergey Abakumov, Taoufik Rohand, Volker Leen, Peter Dedecker, Tanja Weil, Johan Hofkens   +8 more
wiley   +2 more sources

Decentralized optimization for effective coordination of transmission and distribution systems with dynamic DER aggregation. [PDF]

Sci Rep
Raghunathan N, Wang Z, Chen F, Yan B.
europepmc   +1 more source

A low-profile antenna with parasitic elements and a DGS-based partial ground plane for 5G/WMAN applications [PDF]

Liton Chandra Paul, Md. Tanvir Rahman Jim, Tithi Rani, S. M. Muyeen, Muharrem Karaaslan, Sk. A. Shezan, Md. Fatin Ishraque, Volkan Akdoğan   +7 more
openalex   +1 more source

Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

Annals of Neurology, EarlyView.
We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton, Yingxin He, Melissa M. Budelier, Nicolas Barthélemy, Margaret D. Ireland, Miwei Hu, Danielle Graham, Toby Ferguson, James D. Berry, Randall J. Bateman, Timothy M. Miller, Cindy V. Ly   +11 more
wiley   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, EarlyView.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

ADAT novel time-series-aware adaptive transformer architecture for sign language translation. [PDF]

Sci Rep
Shahin N, Ismail L.
europepmc   +1 more source

DYNAMIC GEOMETRY SYSTEMS (DGS) - SOFTWARE SUPPORT FOR EDUCATION [PDF]

, 2011
Katarína ŽILKOVÁ
openalex   +1 more source

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis

Annals of Neurology, EarlyView.
The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age‐related brain atrophy in a population‐based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross‐sectional and ...
Cato E. A. Corsten, Ana M. Marques, Elisabeth J. Vinke, C. Louk de Mol, Rinze F. Neuteboom, M. Kamran Ikram, Mohsen Ghanbari, Frank J. Wolters, Beatrijs Wokke, Meike W. Vernooij, Joost Smolders   +10 more
wiley   +1 more source

High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective SOD1 is the second most frequently mutated gene in European patients with amyotrophic lateral sclerosis (ALS). Given the recent authorization of SOD1‐targeted antisense oligonucleotides for SOD1‐ALS, prompt screening for SOD1 mutations in patients with ALS patients is highly recommended.
Delia Gagliardi, Chiara Villella, Matteo Zanovello, Virginia Iacobelli, Stefania Corti, Giacomo Pietro Comi, Pietro Fratta, Henry Houlden, Arianna Tucci, Dario Ronchi   +9 more
wiley   +1 more source