Results 101 to 110 of about 58,993 (239)

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The Movement Disorder Society‐Unified Parkinson's Disease Rating Scale‐Part III (MDS‐UPDRS‐III) is subjective and insensitive to subtle changes in patients with Parkinson's disease (PD). Computer vision (CV) can extract objective kinematics from routine outpatient videos, potentially augmenting the accuracy of the motor assessment ...
Pasquale Maria Pecoraro, Luca Marsili, Antonio Cannavacciuolo, Kevin R. Duque, Jesus Abanto, Jennifer Sharma, Jennifer Scheler, Heba A. Deraz, Lauren Wingler, Vincenzo Di Lazzaro, Alberto J. Espay, Lazzaro di Biase, Matteo Bologna   +12 more
wiley   +1 more source

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, EarlyView.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source

Stabilized Cellulase in Chitosan–Polyvinyl Alcohol Biopolymer Beads for Sustainable Enzymatic Deinking of Recycled Paper

ChemistryOpen, EarlyView.
A stable and reusable biocatalyst, cellulase@Cs/PVA/Ga, is engineered by immobilizing cellulase onto glutaraldehyde‐activated chitosan (Cs) and coating it with polyvinyl alcohol. This composite system enhances enzymatic stability and efficiency for the sustainable deinking of recycled newspaper, offering a green alternative to harsh chemical treatments.
Parisa Chakeri, Ghasem Mohammadi‐Nejad, Ghasem Hosseini Salekdeh, Shohreh Ariaeenejad, Azadeh Lohrasbi‐Nejad   +4 more
wiley   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Countering Religious Extremism Through Social Reforms: An Islamic Perspective

The Islamic Culture, 2020
The existence of any states based on reasons to exit and so true with Pakistan as well. Pakistan’s existence is related to her ideology which is based on being a truly democratic Islamic state.
Faheem Akhter, Khalid Mehmood Iraqi
doaj  

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

ECONOMIC AND SOCIAL DEVELOPMENT THROUGH SPECIAL ECONOMIC ZONES (SEZS): WORKABLE STRATEGIES FOR PAKISTAN

Margalla Papers
Special Economic Zones (SEZs) form part of the industrial growth strategies of the respective countries to stimulate economic growth and community development.
Muhammad Zafar Iqbal, Bashir Ahmad
doaj  

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

Benthic Macroinvertebrate Recovery After Wastewater Treatment Plant Upgrades: Implications for Biomonitoring

River Research and Applications, EarlyView.
ABSTRACT During the past decade, major upgrades have been made to the Kitchener and Waterloo wastewater treatment plants (WWTPs) in the Grand River watershed in Ontario, Canada. As part of efforts to evaluate the effectiveness of these investments (>$450 M CDN), a benthic macroinvertebrate (BMI) monitoring program was initiated by sampling upstream and
Sean McLay, Mark R. Servos, Leslie M. Bragg, Dominika Celmer‐Repin, Hadi A. Dhiyebi, Azar Fattahi, Keegan A. Hicks, Edward M. Krynak, Mitchell Kay, Adam G. Yates   +9 more
wiley   +1 more source