Results 141 to 150 of about 17,560 (201)

Machine learning algorithms to accelerate etiological diagnosis of congenital disorders of adrenal steroidogenesis.

J Clin Endocrinol Metab
Gurpinar Tosun B, Ercetin AN, Turan S, Bereket A, Arga KY, Guran T.   +5 more
europepmc   +1 more source

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DHEA, DHEAS and PCOS

The Journal of Steroid Biochemistry and Molecular Biology, 2015
Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although observations in patients with inherited APA excess (e.g., patients with 21-hydroxylase ...
Mark O, Goodarzi, Enrico, Carmina, Ricardo, Azziz   +2 more
openaire   +2 more sources

DHEA and DHEA‐S: A Review

The Journal of Clinical Pharmacology, 1999
Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to ...
P D, Kroboth, F S, Salek, A L, Pittenger, T J, Fabian, R F, Frye   +4 more
openaire   +2 more sources

Selective Microbial Conversion of DHEA into 7α-OH-DHEA

2023
7α-Hydroxy dehydroepiandrosterone (7α-OH-prasterone, 7α-OH-DHEA) is a key steroid intermediate in the synthesis of valuable pharmaceuticals widely used in the treatment of autoimmune illness, rheumatoid arthritis, colitis, and other severe diseases. The steroid can be produced using a filamentous fungus, which is capable of regio- and stereospecific ...
Vyacheslav V, Kollerov, Andrei A, Shutov, Marina V, Donova   +2 more
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Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer’s Disease

Current Alzheimer Research, 2020
Background:Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer’s ...
Nedić Erjavec, Gordana, Nikolac Perković, Matea, Pivac, Nela, Tudor, Lucija, Švob Štrac, Dubravka, Konjevod, Marcela   +5 more
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Biotransformation of DHEA into 7α,15α-diOH-DHEA

2017
3β,7α,15α-Trihydroxy-5-androsten-17-one (7α,15α-diOH-DHEA) is a key intermediate of the novel oral contraceptive "Yasmin" (widely used in birth control pills and postmenopausal hormone replacement therapy pills; the active ingredient is drospirenone).
Hui, Li, Jin, Sun, Zhenghong, Xu
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Lack of Hepatic Conversion of Dehydroepiandrosterone Sulfate (DHEAS) to DHEA

Endocrine Research, 2004
DHEA and its sulfate ester DHEAS are the most abundant steroids in the human circulation. Only desulfated DHEA is biologically active and can be converted downstream toward sex steroids. The current concept is that DHEAS serves as the hydrophilic storage pool for DHEA regeneration and that DHEA and DHEAS are interconverted freely via hydroxysteroid ...
F, Hammer, S, Subtil, P, Sanning, D, Filko, P, Lux, B, Allolio, W, Arlt   +6 more
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DHEA and Sport

Clinical Journal of Sport Medicine, 2002
Dehydroepiandrosterone (DHEA), a 19-carbon steroid, is situated along the steroid metabolic pathway. It is the most abundant circulating hormone in the body and can be converted to either androgens or estrogens. It is readily conjugated to its sulphate ester DHEAS, and they are designated as DHEA(S) here when used together. Its secretion reaches a peak
openaire   +2 more sources