Results 1 to 10 of about 40,426 (262)

Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

Antibiotics, 2021
Herein, a series of novel hybrid sulfaguanidine moieties, bearing 2-cyanoacrylamide 2a–d, pyridine-2-one 3–10, and 2-imino-2H-chromene-3-carboxamide 11, 12 derivatives, were synthesized, and their structure confirmed by spectral data and elemental ...
Ahmed Ragab, Sawsan A Fouad, Ahmed A Askar   +2 more
exaly   +2 more sources

Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone‐based derivatives as DHFR inhibitors [PDF]

Drug development research (Print), 2023
Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and antitumor activities.
Eman O Osman, S. H. Emam, Amr Sonousi, M. Kandil, Amr M Hilal Abdou, R. A. Hassan   +5 more
semanticscholar   +2 more sources

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

Molecules, 2019
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents.
Maria Valeria Raimondi, Mery La Franca, Giampaolo Barone   +2 more
exaly   +2 more sources

Fusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production. [PDF]

PLoS ONE, 2012
Amplification of the dihydrofolate reductase gene (Dhfr) by methotrexate (Mtx) exposure is commonly used for recombinant protein expression in Chinese hamster ovary (CHO) cells.
Chiemi Noguchi, Yoshio Araki, Daisuke Miki, Noriaki Shimizu   +3 more
doaj   +2 more sources

Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition

European Journal of Medicinal Chemistry, 2017
Tarosh S Patel, Bharat C Dixit
exaly   +2 more sources

Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies.

Biochemistry, 2016
Zhen Wang, D. Antoniou, S. Schwartz, V. Schramm   +3 more
semanticscholar   +2 more sources

A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa. [PDF]

Journal of Infectious Diseases, 2007
Oumou Maïga, A. Djimde, V. Hubert, E. Renard, A. Aubouy, F. Kironde, Basile Nsimba, K. Koram, O. Doumbo, J. Le bras, J. Clain   +10 more
semanticscholar   +2 more sources

Prevalence of antimalaria drug resistance-conferring mutations associated with sulphadoxine-pyrimethamineine-resistant Plasmodium falciparum in East Africa: a systematic review and meta-analysis [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background The emergence and spread of drug resistance to antimalarial drugs pose a severe threat to effective malaria control and treatment. Although sulfadoxine-pyrimethamine resistance is well-documented, it is still the drug of choice for treating ...
Wagaw Abebe, Agenagnew Ashagre, Tadesse Misganaw, Zelalem Dejazmach, Getinet Kumie, Marye Nigatie, Abdu Jemal, Zelalem Asmare, Woldeteklehaymanot Kassahun, Solomon Gedfie, Ermias Getachew, Muluken Gashaw, Sisay Ayana, Yalewayker Gashaw, Assefa Sisay, Selamyhun Tadesse, Tegegne Eshetu, Mulat awoke, Birhanu Kassanew, Atitegeb Abera Kidie, Biruk Beletew Abate, Melese Abate Reta   +21 more
doaj   +2 more sources

Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR. [PDF]

Structure, 2014
D. Keedy, H. van den Bedem, David A. Sivak, G. Petsko, D. Ringe, M. Wilson, J. Fraser   +6 more
semanticscholar   +2 more sources

Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Plasmodium falciparum dhfr-dhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon

Pathogens, 2023
Intermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine (IPTp-SP) is a key component in the malaria control strategy implemented in Africa. The aim of this study was to determine IPTp-SP adherence and coverage, and the impact on
Carole Else Eboumbou Moukoko, Loick Pradel Kojom Foko, Angèle Ayina, Bernard Tornyigah, Annie Rachel Epote, Ida Calixte Penda, Patricia Epee Eboumbou, Serge Bruno Ebong, Gaetan Texier, Sandrine Eveline Nsango, Lawrence Ayong, Nicaise Tuikue Ndam, Albert Same Ekobo   +12 more
doaj   +1 more source