Computer-Assisted Modeling and Examination of Protein-Molecule Complexes
CHIMIA, 1984 Three applications of the new Roche Interactive Molecular Graphics system are outlined. They include (i) the computer-assisted fitting of various brodimoprim derivatives into the active sites of L.casei and E.coli dihydrofolate reductases (DHFR), (ii ...
Klaus Müller
doaj +1 more source
Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space [PDF]
, 1992 Cytochrome b2 reaches the intermembrane space of mitochondria by transport into the matrix followed by export across the inner membrane. While in the matrix, the protein interacts with hsp60, which arrests its folding prior to export.
Guiard, Bernard +6 more
core +1 more source
A natural killer cell receptor specific for a major histocompatibility complex class I molecule. [PDF]
, 1994 Target cell expression of major histocompatibility complex (MHC) class I molecules correlates with resistance to lysis by natural killer (NK) cells.
Daniels, BF +3 more
core
Ligand binding and circular permutation modify residue interaction network in DHFR.
PLoS Computational Biology, 2007 Residue interaction networks and loop motions are important for catalysis in dihydrofolate reductase (DHFR). Here, we investigate the effects of ligand binding and chain connectivity on network communication in DHFR.
Zengjian Hu +6 more
doaj +1 more source
Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial. [PDF]
, 2011 BACKGROUND: Intermittent preventive treatment of malaria in children (IPTc) is a promising new approach to the control of malaria in areas of seasonal malaria transmission but it is not known if IPTc adds to the protection provided by an insecticide ...
Chandramohan, Daniel +17 more
core +3 more sources
Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo
Molecular Therapy: Methods & Clinical Development, 2019 The E. coli dihydrofolate reductase (DHFR) destabilizing domain (DD), which shows promise as a biologic tool and potential gene therapy approach, can be utilized to achieve spatial and temporal control of protein abundance in vivo simply by ...
Hui Peng +11 more
doaj +1 more source
Stealing Links from Graph Neural Networks
, 2020 Graph data, such as chemical networks and social networks, may be deemed confidential/private because the data owner often spends lots of resources collecting the data or the data contains sensitive information, e.g., social relationships.
Backes, Michael +4 more
core
Journal of Cell Biology, 1996 Dihydrofolate reductase fusion proteins have been widely used to study conformational properties of polypeptides translocated across membranes. We have studied the import of dihydrofolate reductase fusion proteins into glycosomes and mitochondria of ...
Thomas Hiiusler +3 more
semanticscholar +1 more source
A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism
Cell Reports, 2019 Summary: Enzyme function and evolution are influenced by the larger context of a metabolic pathway. Deleterious mutations or perturbations in one enzyme can often be compensated by mutations to others.
Andrew F. Schober +8 more
doaj +1 more source