Results 121 to 130 of about 39,011 (239)

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Cell Reports, 2019
Summary: Enzyme function and evolution are influenced by the larger context of a metabolic pathway. Deleterious mutations or perturbations in one enzyme can often be compensated by mutations to others.
Andrew F. Schober, Andrew D. Mathis, Christine Ingle, Junyoung O. Park, Li Chen, Joshua D. Rabinowitz, Ivan Junier, Olivier Rivoire, Kimberly A. Reynolds   +8 more
doaj   +1 more source

A natural killer cell receptor specific for a major histocompatibility complex class I molecule. [PDF]

, 1994
Target cell expression of major histocompatibility complex (MHC) class I molecules correlates with resistance to lysis by natural killer (NK) cells.
Daniels, BF, Karlhofer, FM, Seaman, WE, Yokoyama, WM   +3 more
core  

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

Malaria Journal, 2010
Background Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's
White Nicholas J, Day Nicholas PJ, Songtawee Napat, Theppabutr Sasikrit, Choowongkomon Kiattawee, Woodrow Charles J, Imwong Mallika   +6 more
doaj   +1 more source

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

Malaria Journal, 2011
Background Plasmodium vivax is the most prevalent cause of human malaria in tropical regions outside the African continent. The lack of a routine continuous in vitro culture of this parasite makes it difficult to develop specific drugs for this disease ...
Yuthavong Yongyuth, Srichairatanakool Somdet, Prommana Parichat, Uthaipibull Chairat, Somsak Voravuth, Kamchonwongpaisan Sumalee   +5 more
doaj   +1 more source

Posttranscriptional control of DHFR gene expression during adenovirus 2 infection [PDF]

, 1985
S S Yoder, Susan M. Berget
openalex   +1 more source

Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles.

Journal of Infectious Diseases, 2006
BACKGROUND Sulfadoxine-pyrimethamine has been widely used as first-line therapy for uncomplicated malaria throughout sub-Saharan Africa. Recent studies conducted in Asia and Africa suggest the triple-mutant dhfr genotype (51I/59R/108N) may have been ...
A. McCollum, Amanda C. Poe, M. Hamel, Curtis S. Huber, Zhiyong Zhou, Y. Shi, P. Ouma, J. Vulule, P. Bloland, L. Slutsker, J. Barnwell, V. Udhayakumar, A. Escalante   +12 more
semanticscholar   +1 more source

Moderate-Level Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells is Accompanied by Chromosomal Translocations At or Near the Site of the Amplified DHFR Gene [PDF]

, 1984
Wayne F. Flintoff, Elizabeth Livingston, Catherine Duff, Ronald G. Worton   +3 more
openalex   +1 more source

Two RFLPs for the human dihydrofolate reductase gene (DHFR) [PDF]

, 1987
John N. Feder, A. Bowcock, Luigi Luca Cavalli-Sforza, Robert Schimke   +3 more
openalex   +1 more source

Stealing Links from Graph Neural Networks

, 2020
Graph data, such as chemical networks and social networks, may be deemed confidential/private because the data owner often spends lots of resources collecting the data or the data contains sensitive information, e.g., social relationships.
Backes, Michael, Gong, Neil Zhenqiang, He, Xinlei, Jia, Jinyuan, Zhang, Yang   +4 more
core  

The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics

Malaria Journal, 2007
Background The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism.
Elbashir Mustafa I, Masuadi Emad M, Bygbjerg Ib C, Khalil Insaf F, Alifrangis Michael, A-Elbasit Ishraga E, Giha Hayder A   +6 more
doaj   +1 more source