Results 221 to 230 of about 39,011 (239)

Synthesis, characterization and bio-evaluation of novel series of pyrazoline derivatives as potential antifungal agents. [PDF]

Sci Rep
Yadav CS, Krishna A, Singh SP, Kishan J, Chopra S, Srivastava K, Guha R, Lohani MB, Ahmad V, Alghamdi AA, Khan AR, Azad I.   +11 more
europepmc   +1 more source

A proteolytic AAA+ machine poised to unfold protein substrates. [PDF]

Nat Commun
Ghanbarpour A, Sauer RT, Davis JH.
europepmc   +1 more source

Anti-lymphoma Activity of Acyclic Terpenoids and Its Structure-Activity Relationship: In Vivo, In Vitro, and In Silico Studies. [PDF]

Int J Mol Sci
Calzada F, Ramírez-Santos J, Ordoñez-Razo RM, Valdes M, Velázquez C, Barbosa E.   +5 more
europepmc   +1 more source

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DihydrofolateReductase (DHFR) Inhibitors: A Comprehensive Review.

Current Medicinal Chemistry, 2023
BACKGROUND Dihydrofolate reductase (DHFR) is an indispensable enzyme required for the survival of most prokaryotic and eukaryotic cells as it is involved in the biosynthesis of essential cellular components.
Renu Sehrawat, P. Rathee, Sarita Khatkar, E. Akkol, M. Khayatkashani, S. Nabavi, A. Khatkar   +6 more
semanticscholar   +1 more source

3D-QSAR, molecular docking, DFT and ADMET studies on quinazoline derivatives to explore novel DHFR inhibitors

Journal of Biomolecular Structure and Dynamics, 2021
Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase (DHFR) genes. These mutations affect the amino acids at positions 51, 59, 108 and 164 of DHFR, which appear to play a major role in malaria treatment failure ...
Hanine Hadni, M. Bakhouch, M. Elhallaoui
semanticscholar   +1 more source

Recent Design and Structure-Activity Relationship Studies on Modifications of DHFR Inhibitors as Anticancer Agents.

Current Medicinal Chemistry, 2019
BACKGROUND Dihydrofolate reductase (DHFR) has been known for decades as a molecular target for antibacterial, antifungal and anti-malarial treatments.
Agnieszka Wróbel, D. Drozdowska
semanticscholar   +1 more source

Repositioning of DHFR Inhibitors.

Current Topics in Medicinal Chemistry, 2016
Development of new drugs is a time-consuming, hugely expensive and an uncertain endeavor. The pharmaceutical industry is looking for cost-effective alternatives with reduced risks of drug failure.
A. Lele, Deepak Mishra, T. K. Kamil, S. Bhakta, M. Degani   +4 more
semanticscholar   +1 more source

Study of DHPS and DHFR genes of Pneumocystis jirovecii in Thai HIV-infected patients.

Medical Mycology, 2008
The combination of trimethoprim-sulfamethoxazole is widely used for the prophylaxis and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii.
S. Siripattanapipong, S. Leelayoova, M. Mungthin, J. Worapong, P. Tan-ariya   +4 more
semanticscholar   +1 more source

Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort

Infection, 2017
I. Suárez, Lisa Roderus, Edeltraud van Gumpel, N. Jung, C. Lehmann, G. Fätkenheuer, P. Hartmann, G. Plum, J. Rybniker   +8 more
semanticscholar   +1 more source

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

Cell, 1987
I. Mellon, G. Spivak, P. Hanawalt
semanticscholar   +1 more source