Results 41 to 50 of about 39,011 (239)

Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A

BMC Research Notes, 2018
Objective Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. Withaferin-A (WA)
Bharadwaja Vadloori, A. K. Sharath, N. Prakash Prabhu, Radheshyam Maurya   +3 more
doaj   +1 more source

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

Cell Death and Disease, 2022
High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS).
Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng   +7 more
doaj   +1 more source

Old Doubts From a New Perspective: Oral Versus Subcutaneous Methotrexate. [PDF]

Int J Dermatol
International Journal of Dermatology, Volume 64, Issue 9, Page 1535-1537, September 2025.
Kiss L, Gyulai R.
europepmc   +2 more sources

Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

Cancer Cell International, 2016
BackgroundMethotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid. DHFR-mediated effects are apparently responsible for its primary antineoplastic action.
M. Šrámek, J. Neradil, J. Štěrba, R. Veselska   +3 more
semanticscholar   +1 more source

Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study

Malaria Journal, 2017
Background The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine–pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10% in highland areas of southwest Uganda and eastern Rwanda.
Caroline A. Lynch, Richard Pearce, Hirva Pota, Connie Egwang, Thomas Egwang, Amit Bhasin, Jonathan Cox, Tarekegn A. Abeku, Cally Roper   +8 more
doaj   +1 more source

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.

PLoS Neglected Tropical Diseases, 2021
Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced in Leishmania by the bifunctional dihydrofolate reductase thymidylate synthase (DHFR-TS) and by
Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette   +2 more
doaj   +1 more source

The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

Scientific Reports, 2015
It is an urgent need to develop new drugs for Mycobacterium tuberculosis (Mtb) and the enzyme, dihydrofolate reductase (DHFR) is a recognised drug target.
Wei Hong, Yu Wang, Z. Chang, Yanhui Yang, Jing Pu, Tao Sun, S. Kaur, J. Sacchettini, Hunmin Jung, Wee Lin Wong, Lee Fah Yap, Yun Fong Ngeow, I. Paterson, Hao Wang   +13 more
semanticscholar   +1 more source

Conformational Dynamics of the Plug Domain of the SecYEG Protein-conducting Channel [PDF]

, 2011
The central pore of the SecYEG preprotein-conducting channel is closed at the periplasmic face of the membrane by a plug domain. To study its conformational dynamics, the plug was labeled site-specifically with an environment-sensitive fluorophore.
Arkowitz, Baneyx, Becker, Bol, Bonardi, Bondar, Cabelli, De Keyzer, Driessen, du Plessis, Duong, Egea, Evans, Fekkes, Frauenfeld, Greenough, Gumbart, Hanahan, Harris, Joly, Junne, Klose, Kusters, Lakowicz, Li, Lin, Lycklama, Maillard, Manting, Ménétret, Nakatogawa, Osborne, Plath, Prinz, Ramachandran, Rutkowska, Schaffitzel, Smith, Tam, Tsukazaki, Van den Berg, van der Does, van der Sluis, Zhang, Zimmer   +44 more
core   +2 more sources

Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine

PLoS ONE, 2015
Background The emergence and spread of drug resistance represents one of the biggest challenges for malaria control in endemic regions. Sulfadoxine-pyrimethamine (SP) is currently deployed as intermittent preventive treatment in pregnancy (IPTp) to ...
M. Tahita, H. Tinto, A. Erhart, A. Kazienga, Robert J. Fitzhenry, C. VanOvermeir, Anna Rosanas-Urgell, J. Ouédraogo, R. Guiguemdé, J. Van geertruyden, U. d’Alessandro   +10 more
semanticscholar   +1 more source

Multiple prebiotic metals mediate translation. [PDF]

, 2018
Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a ...
Bowman, Jessica C, Bray, Marcus S, Glass, Jennifer B, Haynes, Jay William, Hud, Nicholas V, Lenz, Timothy K, Petrov, Anton S, Reddi, Amit R, Williams, Loren Dean   +8 more
core   +1 more source