Results 41 to 50 of about 40,426 (262)

Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study

Malaria Journal, 2017
Background The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine–pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10% in highland areas of southwest Uganda and eastern Rwanda.
Caroline A. Lynch, Richard Pearce, Hirva Pota, Connie Egwang, Thomas Egwang, Amit Bhasin, Jonathan Cox, Tarekegn A. Abeku, Cally Roper   +8 more
doaj   +1 more source

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

Cell Death and Disease, 2022
High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS).
Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng   +7 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus

Scientific Reports, 2017
The larval stage of Echinococcus granulosus causes cystic echinococcosis (CE), a neglected tropical disease that leads to morbidity and mortality in humans and livestock worldwide.
Xingju Song, Dandan Hu, Min Yan, Yu Wang, Ning Wang, Xiaobin Gu, Guangyou Yang   +6 more
doaj   +1 more source

The effect of Point Mutations in Dihydrofolate reductase genes and Multidrug resistance gene 1-86 on treatment of falciparum malaria in Sudan

Journal of Infection in Developing Countries, 2009
Background: One of the major problems to the treatment of malaria is the emergence and spread of parasite resistant to antimalarial drugs. Due to increased chloroquine (CQ) resistance, the antifolate combinations are becoming important in the ...
Rahma Udu Yusuf, Sabah Ahmed Omar, Raphael Muchangi Ngure   +2 more
doaj   +1 more source

The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

Scientific Reports, 2015
It is an urgent need to develop new drugs for Mycobacterium tuberculosis (Mtb) and the enzyme, dihydrofolate reductase (DHFR) is a recognised drug target.
Wei Hong, Yu Wang, Z. Chang, Yanhui Yang, Jing Pu, Tao Sun, S. Kaur, J. Sacchettini, Hunmin Jung, Wee Lin Wong, Lee Fah Yap, Yun Fong Ngeow, I. Paterson, Hao Wang   +13 more
semanticscholar   +1 more source

Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia. [PDF]

, 2005
In the Maheba Refugee Settlement, in the clinics supported by Medecins Sans Frontieres, all children aged up to 5 years with a confirmed diagnosis of uncomplicated falciparum malaria are treated with the combination of sulfadoxine/pyrimethamine (SP) and ...
Bloland PB, Contamin H, National Malaria Control Centre, Nosten F, Peterson DS, Trape JF, Vasconcelos KF, White NJ, World Health Organisation (WHO), World Health Organisation (WHO)   +9 more
core   +2 more sources

Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24

ImmunoMedicine, 2022
Immune checkpoint inhibitors (ICIs) have improved the clinical management of some cancer cases, yet patients still fail to respond to immunotherapy.
Austin C. Boese, Jung Seok Hwang, Isabelle Young, Courteney M. Malin, Vanessa Avalos, JiHoon Kang, Sumin Kang   +6 more
doaj   +1 more source

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity

Metabolites, 2023
Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinically
Jennifer I. Brown, Peng Wang, Alan Y. L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D. G. Page   +15 more
doaj   +1 more source

Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine

PLoS ONE, 2015
Background The emergence and spread of drug resistance represents one of the biggest challenges for malaria control in endemic regions. Sulfadoxine-pyrimethamine (SP) is currently deployed as intermittent preventive treatment in pregnancy (IPTp) to ...
M. Tahita, H. Tinto, A. Erhart, Adama Kazienga, Robert J. Fitzhenry, C. VanOvermeir, A. Rosanas-Urgell, J. Ouédraogo, R. Guiguemdé, J. Van geertruyden, U. d’Alessandro   +10 more
semanticscholar   +1 more source