Results 51 to 60 of about 40,426 (262)

Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso

Parasite, 2016
Background: The emergence of resistance to artemisinin derivatives in western Cambodia is threatening to revert the recent advances made toward global malaria control and elimination.
Somé Anyirékun Fabrice, Sorgho Hermann, Zongo Issaka, Bazié Thomas, Nikiéma Frédéric, Sawadogo Amadé, Zongo Moussa, Compaoré Yves-Daniel, Ouédraogo Jean-Bosco   +8 more
doaj   +1 more source

Markers of sulfadoxine–pyrimethamine resistance in Eastern Democratic Republic of Congo; implications for malaria chemoprevention

Malaria Journal, 2019
Background Sulfadoxine–pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC).
Marit van Lenthe, Renske van der Meulen, Maryvonne Lassovski, Adelaide Ouabo, Edwige Bakula, Colette Badio, Deogratias Cibenda, Lucy Okell, Erwan Piriou, Lynn Grignard, Kjerstin Lanke, Bhargavi Rao, Teun Bousema, Cally Roper   +13 more
doaj   +1 more source

Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh. [PDF]

, 2004
OBJECTIVE: To assess the efficacy of antimalarial treatment and molecular markers of Plasmodium falciparum resistance in the Chittagong Hill Tracts of Bangladesh. METHODS: A total of 203 patients infected with P.
Anderson, T C, Brockman, A, Chakma, S, Nair, S, Talukder, L, van den Broek, I, van der Wardt, S   +6 more
core   +2 more sources

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations

, 2012
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining ...
Benkovic, Bershtein, Dams, DePristo, Ding, Dobson, Drummond, E. I. Shakhnovich, Elena, Fernandez, Gronenborn, Ispolatov, Lukatsky, Malevanets, Park, Parsell, Privalov, Privalov, Robertson, Rousseau, Rousseau, S. Bershtein, Shakhnovich, Soskine, Taniguchi, Taverna, W. Mu, Weinreich, Wright, Yang   +29 more
core   +1 more source

Mitochondrial molecular chaperones [PDF]

, 1994
After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio, Caplan, Caplan, Cheng, Craig, Cyr, Deshales, Eilers, Gambill, Glick, Glick, Hartl, Hartl, Hwang, Johnson, Kang, Kiebler, Langer, Liberek, Manning-Krieg, Neupert, Ostermann, Palleros, Rassow, Rospert, Sanders, Scherer, Schleyer, Schröder, Simon, Vestweber, Voos, Xia   +32 more
core   +1 more source

Novel 3D‐Printed Biophotonic Scaffold Displaying Luminescence under Near‐Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release

Advanced Healthcare Materials, EarlyView.
Despite significant efforts in developing novel biomaterials to regenerate tissue, only a few of them have successfully reached clinical use. It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial‐temporal manner, and trigger ...
Sonya Ghanavati, Ekin Opar, Virginia Alessandra Gobbo, Carlo Matera, Fabio Riefolo, Rossella Castagna, Julien Colombelli, Andrew Draganski, Joshua Baggott, Mika Lastusaari, Pau Gorostiza, Laeticia Petit, Jonathan Massera   +12 more
wiley   +1 more source

Homology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparum

Malaria Journal, 2004
Background The aim of this study was to develop site-specific antibodies as a tool to capture Plasmodium falciparum-dihydrofolate reductase (Pf-DHFR) from blood samples from P.
Chen Ming, Weng Jimmy E, Rønn Anita M, Jørgensen Flemming S, Christensen Inge T, Alifrangis Michael, Bygbjerg Ib C, Sirawaraporn Worachart, Palarasah Yaseelan, Koch Claus   +9 more
doaj   +1 more source

Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging

iScience, 2022
Summary: The Escherichia coli dihydrofolate reductase (DHFR) destabilizing domain (DD) serves as a promising approach to conditionally regulate protein abundance in a variety of tissues.
Hui Peng, Prerana Ramadurgum, DaNae R. Woodard, Steffi Daniel, Emi Nakahara, Marian Renwick, Bogale Aredo, Shyamtanu Datta, Bo Chen, Rafael Ufret-Vincenty, John D. Hulleman   +10 more
doaj   +1 more source

Computer simulation of protein systems [PDF]

, 1984
Ligand binding to dihydrofolate reductase (DHFR) is discussed. This is an extremely important enzyme, as it is the target of several drugs (inhibitors) which are used clinically as antibacterials, antiprotozoals and in cancer chemotherapy. DHFR catalyzes
Dauber-Osguthorpe, P., Hagler, A. T., Kitson, D. H., Osguthorpe, D. J., Wolff, J.   +4 more
core   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source