Results 51 to 60 of about 39,011 (239)

The effect of Point Mutations in Dihydrofolate reductase genes and Multidrug resistance gene 1-86 on treatment of falciparum malaria in Sudan

Journal of Infection in Developing Countries, 2009
Background: One of the major problems to the treatment of malaria is the emergence and spread of parasite resistant to antimalarial drugs. Due to increased chloroquine (CQ) resistance, the antifolate combinations are becoming important in the ...
Rahma Udu Yusuf, Sabah Ahmed Omar, Raphael Muchangi Ngure   +2 more
doaj   +1 more source

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity

Metabolites, 2023
Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinically
Jennifer I. Brown, Peng Wang, Alan Y. L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D. G. Page   +15 more
doaj   +1 more source

Mitochondrial molecular chaperones [PDF]

, 1994
After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio, Caplan, Caplan, Cheng, Craig, Cyr, Deshales, Eilers, Gambill, Glick, Glick, Hartl, Hartl, Hwang, Johnson, Kang, Kiebler, Langer, Liberek, Manning-Krieg, Neupert, Ostermann, Palleros, Rassow, Rospert, Sanders, Scherer, Schleyer, Schröder, Simon, Vestweber, Voos, Xia   +32 more
core   +1 more source

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus

Scientific Reports, 2017
The larval stage of Echinococcus granulosus causes cystic echinococcosis (CE), a neglected tropical disease that leads to morbidity and mortality in humans and livestock worldwide.
Xingju Song, Dandan Hu, Min Yan, Yu Wang, Ning Wang, Xiaobin Gu, Guangyou Yang   +6 more
doaj   +1 more source

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations

, 2012
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining ...
Benkovic, Bershtein, Dams, DePristo, Ding, Dobson, Drummond, E. I. Shakhnovich, Elena, Fernandez, Gronenborn, Ispolatov, Lukatsky, Malevanets, Park, Parsell, Privalov, Privalov, Robertson, Rousseau, Rousseau, S. Bershtein, Shakhnovich, Soskine, Taniguchi, Taverna, W. Mu, Weinreich, Wright, Yang   +29 more
core   +1 more source

Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh. [PDF]

, 2004
OBJECTIVE: To assess the efficacy of antimalarial treatment and molecular markers of Plasmodium falciparum resistance in the Chittagong Hill Tracts of Bangladesh. METHODS: A total of 203 patients infected with P.
Anderson, T C, Brockman, A, Chakma, S, Nair, S, Talukder, L, van den Broek, I, van der Wardt, S   +6 more
core   +2 more sources

Markers of sulfadoxine–pyrimethamine resistance in Eastern Democratic Republic of Congo; implications for malaria chemoprevention

Malaria Journal, 2019
Background Sulfadoxine–pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC).
Marit van Lenthe, Renske van der Meulen, Maryvonne Lassovski, Adelaide Ouabo, Edwige Bakula, Colette Badio, Deogratias Cibenda, Lucy Okell, Erwan Piriou, Lynn Grignard, Kjerstin Lanke, Bhargavi Rao, Teun Bousema, Cally Roper   +13 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24

ImmunoMedicine, 2022
Immune checkpoint inhibitors (ICIs) have improved the clinical management of some cancer cases, yet patients still fail to respond to immunotherapy.
Austin C. Boese, Jung Seok Hwang, Isabelle Young, Courteney M. Malin, Vanessa Avalos, JiHoon Kang, Sumin Kang   +6 more
doaj   +1 more source

A molecular perspective on the limits of life: Enzymes under pressure [PDF]

, 2016
From a purely operational standpoint, the existence of microbes that can grow under extreme conditions, or "extremophiles", leads to the question of how the molecules making up these microbes can maintain both their structure and function. While microbes
Bartlett, D. H., Hemley, R. J., Huang, Q., Ichiye, T., Rodgers, J. M., Tran, K. N.   +5 more
core   +2 more sources