Results 61 to 70 of about 40,426 (262)

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

Malaria Journal, 2011
BackgroundDrug resistance contributes to the global malaria burden. Plasmodiumfalciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP).MethodsThe study assessed the ...
G. Mombo-Ngoma, Sunny Oyakhirome, R. Ord, Julian J. Gabor, Katja C Greutélaers, Katharina Profanter, B. Greutélaers, F. Kurth, B. Lell, J. Kun, S. Issifou, C. Roper, P. Kremsner, M. Grobusch   +13 more
semanticscholar   +1 more source

Import of honeybee prepromelittin into the endoplasmic reticulum [PDF]

, 1987
Honeybee prepromelittin is correctly processed and imported by dog pancreas microsomes. Insertion of prepromelittin into microsomal membranes, as assayed by signal sequence removal, does not depend on signal recognition particle (SRP) and docking protein.
Müller, Günter, Zimmermann, Richard
core   +2 more sources

A molecular perspective on the limits of life: Enzymes under pressure [PDF]

, 2016
From a purely operational standpoint, the existence of microbes that can grow under extreme conditions, or "extremophiles", leads to the question of how the molecules making up these microbes can maintain both their structure and function. While microbes
Bartlett, D. H., Hemley, R. J., Huang, Q., Ichiye, T., Rodgers, J. M., Tran, K. N.   +5 more
core   +2 more sources

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Identification of novel Mycobacterium tuberculosis dihydrofolate reductase inhibitors through rational drug design

International Journal of Mycobacteriology, 2016
Objectives/Background: Dihydrofolate reductase (DHFR) is one of the validated drug targets in Mycobacterium tuberculosis (Mtb) infection. DHFR inhibitors have been used to treat various life-threatening diseases such as cancer, malaria, and several ...
Mymoona Akhter
doaj   +1 more source

Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya

Malaria Journal, 2012
BackgroundUnderstanding the origin and spread of mutations associated with drug resistance, especially in the context of combination therapy, will help guide strategies to halt and prevent the emergence of resistance. Unfortunately, studies have assessed
A. McCollum, K. Schneider, S. Griffing, Zhiyong Zhou, S. Kariuki, Feiko Ter-Kuile, Y. Shi, L. Slutsker, A. Lal, V. Udhayakumar, A. Escalante   +10 more
semanticscholar   +1 more source

Scale‐up of a monoclonal antibody CHO fed‐batch production in stirred tank bioreactors: Effect of hydrodynamic conditions and feeding regimen

Biotechnology Progress, EarlyView.
Abstract Key hydrodynamic‐related parameters such as volumetric power input (P/V), impeller configuration, aeration strategy, and maximum gas sparge rate, as well as an appropriate feeding strategy, must be carefully selected to improve production yields in bioreactor.
Lucas Lemire, Sebastian‐Juan Reyes, Yves Durocher, Robert Voyer, Olivier Henry, Phuong Lan Pham   +5 more
wiley   +1 more source

Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Analytical Cellular Pathology, 2019
This study was to validate changes in the levels of folate receptor-α (FOLR1), dihydrofolate reductase (DHFR), and methionine synthase reductase (MTRR) in the tissue of OC patients.
Jia Chen, Li Li
doaj   +1 more source

Unveiling the Efficacy of Sesquiterpenes from Marine Sponge Dactylospongia elegans in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies

Molecules, 2023
Dihydrofolate reductase (DHFR) is a crucial enzyme that maintains the levels of 5,6,7,8-tetrahydrofolate (THF) required for the biological synthesis of the building blocks of DNA, RNA, and proteins.
Abdelsattar M. Omar, Khadijah A. Mohammad, Ikhlas A. Sindi, Gamal A. Mohamed, Sabrin R. M. Ibrahim   +4 more
doaj   +1 more source

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

Malaria Journal, 2010
BackgroundMutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes of Plasmodium falciparum are associated with resistance to anti-folate drugs, most notably sulphadoxine-pyrimethamine (SP). Molecular studies document the
S. Sridaran, Shannon K. McClintock, Luke M Syphard, Karen M. Herman, J. Barnwell, V. Udhayakumar   +5 more
semanticscholar   +1 more source