Results 71 to 80 of about 39,011 (239)

Import of honeybee prepromelittin into the endoplasmic reticulum [PDF]

, 1987
Honeybee prepromelittin is correctly processed and imported by dog pancreas microsomes. Insertion of prepromelittin into microsomal membranes, as assayed by signal sequence removal, does not depend on signal recognition particle (SRP) and docking protein.
Müller, Günter, Zimmermann, Richard
core   +2 more sources

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Analytical Cellular Pathology, 2019
This study was to validate changes in the levels of folate receptor-α (FOLR1), dihydrofolate reductase (DHFR), and methionine synthase reductase (MTRR) in the tissue of OC patients.
Jia Chen, Li Li
doaj   +1 more source

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

Malaria Journal, 2011
BackgroundDrug resistance contributes to the global malaria burden. Plasmodiumfalciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP).MethodsThe study assessed the ...
G. Mombo-Ngoma, Sunny Oyakhirome, R. Ord, Julian J. Gabor, Katja C Greutélaers, Katharina Profanter, B. Greutélaers, F. Kurth, B. Lell, J. Kun, S. Issifou, C. Roper, P. Kremsner, M. Grobusch   +13 more
semanticscholar   +1 more source

Entwicklung von chemischen Initiatoren der Dimerisierung von HaloTag und SNAP‐Tag zur Untersuchung von Signaltransduktion induziert durch Rezeptor‐Oligomerisierung

Angewandte Chemie, EarlyView.
Die Kontrolle von Protein‐Interaktionen ist entscheidend für das Verständnis von Signaltransduktionsprozessen. Antikörperbasierte Methoden stoßen dabei an ihre Grenzen, doch chemische Dimerisierungsinduktoren (CIDs), die HaloTags und SNAP‐Tags nutzen, ermöglichen eine präzise Steuerung.
Michael Trumpp, Blaise Gatin‐Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau, Johannes Broichhagen   +8 more
wiley   +1 more source

Translational Modulation of Proteins Expressed from Bicistronic Vectors

Molecular Imaging, 2009
Bicistronic vectors are useful tools for exogenous expression of two gene products from a single promoter element; however, reduced expression of protein from the second cistron compared with the first cistron is a common limitation to this approach.
Prasun J. Mishra, Lata G. Menon, Pravin J. Mishra, Philipp Mayer-Kuckuk, Joseph R. Bertino, Debabrata Banerjee   +5 more
doaj   +1 more source

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

Malaria Journal, 2010
BackgroundMutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes of Plasmodium falciparum are associated with resistance to anti-folate drugs, most notably sulphadoxine-pyrimethamine (SP). Molecular studies document the
S. Sridaran, Shannon K. McClintock, Luke M Syphard, Karen M. Herman, J. Barnwell, V. Udhayakumar   +5 more
semanticscholar   +1 more source

Export of honeybee prepromelittin in Escherichia coli depends on the membrane potential but does not depend on proteins secA and secY [PDF]

, 1989
Honeybee prepromelittin (70 amino acid residues), the precursor of an eukaryotic secretory protein, and a hybrid protein between prepromelittin and mouse dihydrofolate reductase (257 amino acid residues) were expressed in Escherichia coli and ...
Cobet, Werner W. E., Mollay, Christa, Müller, Günter, Zimmermann, Richard   +3 more
core  

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, EarlyView.
Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp, Blaise Gatin‐Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau, Johannes Broichhagen   +8 more
wiley   +1 more source

Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein [PDF]

, 2011
Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins.
Cunningham, Deirdre A., Holder, Anthony A., Howell, Steven A., Kazura, James W., Knuepfer, Ellen, Ogun, Solabomi A., Otto, Thomas D., Pain, Arnab, Tewari, Rita, Xu, Zhengyao   +9 more
core   +8 more sources