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The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression
Archivum Immunologiae et Therapiae Experimentalis, 2017Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks
Chon-Kit Chou +8 more
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Reversibility of the Chronic Effects of Di(2-ethylhexyl)phthalate
Toxicologic Pathology, 2001Fischer-344 rats treated with 12,500 ppm (728 and 879 mg/kg/d for male and females, respectively) and B6C3F 1 mice treated with 6,000 ppm (1,227 and 1,408 mg/kg/d, respectively) di(2-ethylhexyl)phthalate (DEHP) in the diet for 78 weeks were allowed to recover for an additional 26 weeks on ...
R M, David +3 more
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Mass spectrometry of di-(2-ethylhexyl)phthalate metabolites
Biological Mass Spectrometry, 1980The electron impact, methane positive chemical ionization, oxygen negative chemical ionization and collision induced dissociation mass analyzed ion kinetic energy spectra of nine metabolites of di-(2-ethylhexyl)phthalate are presented. The collision induced dissociation mass analyzed ion kinetic energy spectra of selected fragment ions were useful for ...
D J, Harvan +3 more
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Excretion and metabolism of di(2-ethylhexyl)-phthalate in man
Xenobiotica, 1985Di-(2-ethylhexyl)phthalate (DEHP) taken orally by two volunteers (30 mg each) was excreted in the urine to the extent of 11 and 15% of dose. After enzymic hydrolysis the urinary metabolites (derivatives of mono (2-ethylhexyl)phthalate) were methylated and identified by g.l.c.-mass spectrometry (C.I.), and the quantitative distribution of conjugated and
P, Schmid, C, Schlatter
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Exposure of hemodialysis patients to di-2-ethylhexyl phthalate
International Journal of Pharmaceutics, 1999The migration of di-2-ethylhexyl phthalate (DEHP) from dialyzers was studied in 21 patients with chronic renal failure undergoing maintenance hemodialysis. The circulating concentrations of DEHP were measured by high performance liquid chromatography in blood of patients obtained from the inlet and the outlet of the dialyzer during a 4-h dialysis ...
M A, Faouzi +9 more
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BIOTRANSFORMATION OF DI(2-ETHYLHEXYL)PHTHALATE BY RAINBOW TROUT
Environmental Toxicology and Chemistry, 1995AbstractThe biotransformation of di(2-ethylhexyl)phthalate (DEHP) was studied in rainbow trout (Oncorhynchus mykiss) following intravascular administration. Methyl-esterified metabolites were identified using rodent-derived standards and nonlinear gradient elution HPLC; metabolites were confirmed by gas chromatography.
Mace G. Barron +2 more
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Toxicology and Applied Pharmacology, 1989
Acute testicular atrophy results when appropriate dosages of di-(2-ethylhexyl) phthalate (DEHP) or its hydrolysis product mono-2-ethylhexyl phthalate (MEHP) are given to male rats. Events thought to be involved in this pathological effect also occur in cultures of testicular cells in vitro, but require MEHP rather than DEHP.
P W, Albro +4 more
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Acute testicular atrophy results when appropriate dosages of di-(2-ethylhexyl) phthalate (DEHP) or its hydrolysis product mono-2-ethylhexyl phthalate (MEHP) are given to male rats. Events thought to be involved in this pathological effect also occur in cultures of testicular cells in vitro, but require MEHP rather than DEHP.
P W, Albro +4 more
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Biodegradability of di-(2-ethylhexyl) phthalate by a newly isolated bacterium Achromobacter sp. RX
Science of the Total Environment, 2021Yu Zhao, Sijie Zhou
exaly