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Contamination of Commercial Blood Products by Di-2-Ethylhexyl Phthalate and Mono-2-Ethylhexyl Phthalate

Vox Sanguinis, 1981
Blood fractionation products obtained from three different manufacturers were analyzed to determine if either mono-2-ethylhexyl phthalate (MEHP) or di-2-ethylhexyl phthalate (DEHP) were contaminants of any of the fractionated proteins. The only protein fraction to contain DEHP was factor IX (23 micrograms/ml) from one company.
R S, Cole   +4 more
openaire   +2 more sources

Di(2-ethylhexyl) phthalate (DEHP) increases proliferation of epithelial breast cancer cells through progesterone receptor dysregulation.

Environmental Research, 2019
The di(2-ethylhexyl) phthalate (DEHP) is a plasticizer incorporated to plastic matrices of widely used consumer products. However, it is gradually released from these products, resulting in a chronic exposure for humans.
B. Crobeddu   +3 more
semanticscholar   +1 more source

No background concentrations of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in blood of rats

Archives of Toxicology, 2001
We measured the background levels of di(2-ethylhexyl) phthalate (DEHP) and its hydrolytic metabolite mono(2-ethylhexyl) phthalate (MEHP) in blood from naive female Sprague-Dawley rats and in de-ionized charcoal-purified water using an analytical procedure that is based on sample treatment with acetonitrile, n-hexane extraction and analysis by gas ...
W, Kessler   +3 more
openaire   +2 more sources

The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats.

Ecotoxicology and Environmental Safety, 2019
BACKGROUND Plasticizer di-2-ethylhexyl phthalate (DEHP) can induce lipid metabolic disorder. There was a chronic low level inflammatory response in adipose tissue of patients with lipid metabolic disorder.
Liting Zhou   +7 more
semanticscholar   +1 more source

Disposition of orally administered di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate in the rat

Archives of Toxicology, 1985
The disposition of di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) was studied in the rat. Three hours after a single oral dose of DEHP (2.8 g/kg), plasma concentrations of 8.8 +/- 1.7 micrograms/ml DEHP and 63.2 +/- 8.7 micrograms/ml MEHP were reached. MEHP levels declined with a half-life of 5.2 +/- 0.5 h. The ratio of the
O A, Teirlynck, F, Belpaire
openaire   +2 more sources

Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats.

Environmental Toxicology and Pharmacology, 2019
Di(2-ethylhexyl) phthalate (DEHP) is an environmental pollutant that is widely used in medical and consumer products. An epidemiological study has suggested that a large daily intake of DEHP from phthalate-contaminated food may be a risk factor for liver
Zongbiao Zhao   +6 more
semanticscholar   +1 more source

Prenatal and postnatal exposure to di‐(2‐ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta‐analysis

Environmental Research, 2018
Background: Di‐(2‐ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified.
Dongwook Lee   +4 more
semanticscholar   +1 more source

Effect of heat on the conversion of di‐2‐ethylhexyl phthalate to mono‐2‐ ethylhexyl phthalate in human plasma

Transfusion, 1981
Plasma di‐2‐ethylhexyl phthalate (DEHP), which accumulates during blood storage in plastic bags, gives rise to plasma mono‐2‐ethylhexyl phthalate (MEHP). This also in plasma samples awaiting analysis, which are no longer stored in plastic bags. Heating plasma samples at 60 C for 25 to 30 minutes in a water bath effectively halts conversion of DEHP to ...
C C, Peck   +4 more
openaire   +2 more sources

In utero exposure to low doses of genistein and di‐(2‐ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes

Andrology, 2020
Although humans are exposed to mixtures of endocrine disruptor chemicals, few studies have examined their toxicity on male reproduction. We previously found that fetal exposure to a mixture of the phytoestrogen genistein (GEN) and the plasticizer di(2 ...
Casandra Walker   +4 more
semanticscholar   +1 more source

Toxicokinetic Relationship Between Di(2-ethylhexyl) Phthalate (DEHP) and Mono(2-ethylhexyl) Phthalate in Rats

Journal of Toxicology and Environmental Health, Part A, 2007
The toxicokinetic relationship between di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP), a major metabolite of DEHP, was investigated in Sprague-Dawley rats orally treated with a single dose of 14C-DEHP. Urinary excretion of total 14C-DEHP and of its metabolites was followed by liquid scintillation counting (LSC ...
Hyun Jung, Koo, Byung Mu, Lee
openaire   +2 more sources

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