Results 111 to 120 of about 2,935,189 (309)

A Simple and Cost-Effective Approach for In Vitro Production of Sliced siRNAs as Potent Triggers for RNAi

Molecular Therapy: Nucleic Acids, 2017
We have studied the molecular properties of in-vitro-transcribed sliced small interfering RNAs (tsli-siRNAs) as an alternative RNAi agent for chemically synthesized siRNA.
Guihua Sun, Arthur D. Riggs
doaj   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

HbA 1c in relation to incident diabetes and diabetes-related complications in non-diabetic adults at baseline

, 2017
We compared the utility of glycated hemoglobin (HbA1c) and oral glucose tolerance (oGTT) in non-diabetic patients for identifying incident diabetes; all-cause mortality; cardiovascular disease (CVD) mortality; CVD, coronary heart disease (CHD), and ...
Patricia Anne Metcalf, Kyle, C, Tim Kenealy, Cam Kyle, Rod T. Jackson, Jackson, RT, Kenealy, T, Metcalf, PA   +7 more
core   +1 more source

Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]

, 2012
Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Joachim Jankowski, Antonia Vlahou (114470), Vlahou Antonia, Joachim Jankowski (114466), Ariela Benigni (114455), Kossida Sophia, Siwy, Justyna, Mullen, Wiliam, Bernd Mayer (32896), Perco, Paul, Perco, P., Wiliam Mullen (114460), Mischak Harald, Benigni, A., Carlamaria Zoja (114447), Mischak, H., Harald Mischak (103627), Sophia Kossida (113366), Benigni, Ariela, Bernd Mayer, Julie Klein, Justyna Siwy (103595), Klein Julie, Jankowski, J., Justyna Siwy, Kossida, Sophia, Mischak, Harald, Ferdinand H Bahlmann, Vlahou, Antonia, Stevens, Robert, Mayer, B., Zoja, C., Ferdinand H. Bahlmann (114474), Ariela Benigni, Benigni Ariela, Stevens Robert, Mayer Bernd, Kossida, S., Klein, Julie, Wiliam Mullen, Siwy, J., Bahlmann Ferdinand H., Paul Perco (32894), Jankowski, Joachim, Antonia Vlahou, Carlamaria Zoja, Sophia Kossida, Siwy Justyna, Stevens, R., Mullen Wiliam, Mullen, W., Robert Stevens, Zoja, Carlamaria, Perco Paul, Paul Perco, Bahlmann, F.H., Mayer, Bernd, Vlahou, A., Harald Mischak, Klein, J., Robert Stevens (18678), Julie Klein (114451), Bahlmann, Ferdinand H., Zoja Carlamaria, Jankowski Joachim   +64 more
core   +1 more source

Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation “Memories”

EBioMedicine, 2016
The directed differentiation of human cardiomyocytes (CMs) from pluripotent cells provides an invaluable model for understanding mechanisms of cell fate determination and offers considerable promise in cardiac regenerative medicine.
Joshua D. Tompkins, Marc Jung, Chang-yi Chen, Ziguang Lin, Jingjing Ye, Swetha Godatha, Elizabeth Lizhar, Xiwei Wu, David Hsu, Larry A. Couture, Arthur D. Riggs   +10 more
doaj   +1 more source

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Arthritis Care &Research, EarlyView.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley   +2 more
wiley   +1 more source

Quality standards for diabetes care toolkit 2014 [PDF]

, 2014
Provides resources and information to support service planning and delivery regarding diabetes care. Introduction Diabetes mellitus is a long term complex metabolic disorder characterised by high levels of blood glucose and caused by defects in insulin ...

core  

The role of a nurse-led vascular risk reduction clinic in diabetes care [PDF]

, 2008
Background and Aims Type 2 diabetes is characterised by excess vascular morbidity and mortality. Intensive vascular risk reduction in type 2 diabetes patients with microalbuminuria has been shown to significantly reduce future vascular events by 50 ...
MacMahon Tone, Jacqueline
core   +2 more sources

Extracellular vesicles derived from induced pluripotent stem cells mediate anti-inflammatory effects in primary human macrophages

Scientific Reports
Extracellular vesicles derived from induced pluripotent stem cells (iPSC EVs) have immunoregulatory potential with the ability to alter the macrophage phenotype. Modulating the macrophage phenotype towards an anti-inflammatory, pro-resolving state may be
Stephen Fitzsimons, Silvia Oggero, Billy P. Egan, Eugène T. Dillon, María Muñoz-San Martín, Shane Clerkin, Ciarán Kennedy, Jessica Davis, Darrell Andrews, John Crean, Orina Belton   +10 more
doaj   +1 more source

AMPK Therapy—A Little Goes A Long Way

Cells
AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that integrates energetic, nutrient, hormonal, redox, and stress signals to coordinate cellular and whole-body energy homeostasis. Although AMPK was initially characterized
Hannah Ceballos, Eryun Zhang, Wendong Huang   +2 more
doaj   +1 more source