Results 21 to 30 of about 23,544 (244)

Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus

The FASEB Journal, 2022
Water homeostasis is tightly regulated by the kidneys via the process of urine concentration. During reduced water intake, the antidiuretic hormone arginine vasopressin (AVP) binds to the vasopressin receptor type II (V2R) in the kidney to enhance ...
Federica Petrillo, Dmitry Chernyakov, C. Esteva-Font, S. Poulsen, B. Edemir, R. Fenton   +5 more
semanticscholar   +1 more source

Diabetes insipidus in mice with a mutation in aquaporin-2. [PDF]

PLoS Genetics, 2005
Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin. Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin
David J Lloyd, Frank Wesley Hall, Lisa M Tarantino, Nicholas Gekakis   +3 more
doaj   +2 more sources

Lithium-induced kidney injury and fibrosis: A versatile model to explore cellular pathways of injury and repair. [PDF]

Physiol Rep
Abstract Lithium‐induced kidney injury is commonly associated with the development of nephrogenic diabetes insipidus. Longer term lithium exposure is associated with the development of chronic interstitial fibrosis. The mechanisms of lithium‐induced kidney injury are multifaceted, affecting many intracellular cell signaling pathways associated with ...
Mehta P, Slatter T, Walker R.
europepmc   +2 more sources

Editorial Introduction: Advancing Pediatric Endocrinology Through Multidimensional Insights. [PDF]

Clin Endocrinol (Oxf)
Clinical Endocrinology, Volume 103, Issue 4, Page 427-428, October 2025.
Huynh T.
europepmc   +2 more sources

Nephrogenic diabetes insipidus in children (Review).

Experimental and Therapeutic Medicine, 2021
Nephrogenic diabetes insipidus (NDI) is characterized by impaired urinary concentrating ability, despite normal or elevated plasma concentrations of the antidiuretic hormone, arginine vasopressin (AVP). NDI can be inherited or acquired.
C. Duicu, A. Pitea, Oana Maria Săsăran, I. Cozea, Lidia Man, C. Bănescu   +5 more
semanticscholar   +1 more source

Central Diabetes Insipidus in the Background of Lithium Use: Consider Central Causes Despite Nephrogenic as the Most Common

The American journal of case reports, 2022
Patient: Female, 31-year-old Final Diagnosis: Central diabetes insipidus Symptoms: Polydipsia • polyuria Medication: — Clinical Procedure: — Specialty: Endocrinology and Metabolic Objective: Unusual clinical course Background: Nephrogenic diabetes ...
Jeffrey J. Li, Shirley Tan, Takumi Kawashita, Christian A. Tagle, Farbod Farmand   +4 more
semanticscholar   +1 more source

Idiopathic partial central diabetes insipidus

Einstein (São Paulo), 2023
Diabetes insipidus is a rare disorder characterized by the inability to concentrate urine, which results in hypotonic urine and increased urinary volume.
Larissa Fabre, Viviane Calice da Silva
doaj   +1 more source

Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus

Journal of the American Society of Nephrology, 2021
Visual Abstract Significance Statement Water reabsorption along the collecting duct is dependent on the function of aquaporin 2 (AQP2). Currently, information on microRNA (miRNA)-mediated, post-transcriptional regulation of AQP2, which may influence ...
Federica Petrillo, A. Iervolino, T. Angrisano, Sabina Jeleń, Vincenzo Costanzo, M. D'Acierno, Lei Cheng, Qi Wu, I. Guerriero, Maria Cristina Mazzarella, Alfonso De Falco, F. D’Angelo, M. Ceccarelli, M. Caraglia, G. Capasso, R. Fenton, F. Trepiccione   +16 more
semanticscholar   +1 more source

Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus

Clinical and Experimental Nephrology, 2021
Congenital nephrogenic diabetes insipidus (NDI) is primarily caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R). Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity ...
Fumiaki Ando
semanticscholar   +1 more source

Ifosfamide-induced nephrogenic diabetes insipidus responsive to supraphysiologic doses of intravenous desmopressin

Clinical Nephrology - Case Studies, 2021
Nephrogenic diabetes insipidus (DI) refers to the reduction in the ability of the kidney to concentrate urine, which can be caused by partial or complete resistance at the site of action of anti-diuretic hormone (ADH) in the collecting tubules ...
M. Sohail, M. Hassanein, Hernan Rincon-Choles   +2 more
semanticscholar   +1 more source