Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct [PDF]
We tested whether severe congestive heart failure (CHF), a condition associated with excess free-water retention, is accompanied by altered regulation of the vasopressin-regulated water channel, aquaporin-2 (AQP2), in the renal collecting duct.
Andersen, D. +8 more
core +2 more sources
Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase 3β-positive epithelium [PDF]
It was hypothesized that lithium causes accelerated and permanent injury to the postnatally developing kidney through entry into epithelial cells of the distal nephron and inhibition of glycogen synthase kinase-3β (GSK-3β).
Christensen, Sten +5 more
core +1 more source
Psychogenic polydipsia in dogs – a review of pathogenesis, diagnosis and treatment
Polyuria and polydipsia represent a common clinical presentation in dogs and may result from numerous disorders affecting different body systems. Compulsive water consumption is characteristic of psychogenic polydipsia, a primary polydipsia disorder rooted in neurologic, behavioural or environmental factors.
G. Pavlovsky
wiley +1 more source
Disruption of cyclooxygenase-2 prevents down-regulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse [PDF]
Bilateral ureteral obstruction (BUO) in rats is associated with increased cyclooxygenase type 2 (COX-2) expression, and selective COX-2 inhibition prevents downregulation of aquaporins (AQPs) in response to BUO.
Frokiaer, Jorgen +5 more
core +1 more source
Hypokalemia Induced Partial Nephrogenic Diabetes Insipidus: A Case Report
Diabetes insipidus is a condition characterised by a large volume of diluted urine production and increased thirst. In this case report, a 49-year-old gentleman presented with 3 months of polyuria and polydipsia. He had a repeated history of hypokalemia.
Anil Nepali +4 more
doaj +1 more source
Background: Hypernatraemia is a serious condition that can potentially become life threatening. It is known that lithium is associated with polyuria and nephrogenic diabetes insipidus, risk factors for hypernatraemia.
Michael Ott +2 more
doaj +1 more source
Disturbances of sodium in critically ill adult neurologic patients: A clinical review [PDF]
Disorders of sodium and water balance are common in critically ill adult neurologic patients. Normal aspects of sodium and water regulation are reviewed. The etiology of possible causes of sodium disturbance is discussed in both the general inpatient and
Crocker, M +3 more
core
Nephrogenic Diabetes Insipidus Secondary to Obstructive Uropathy – An Unusual Presentation- A Case Report [PDF]
Diabetes insipidus is a clinical condition, characterized by polyuria and polydipsia, that results from either insufficient production or end organ resistance to antidiuretic hormone (ADH).
Huque, Syed Saimul +2 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
We present a female neonate with arthrogryposis, renal tubular abnormalities and cholestasis syndrome and complex renal structural and functional abnormalities that include medul-lary nephrocalcinosis, hydronephrosis, nephrogenic diabetes insipidus ...
Majid Malaki +2 more
doaj +1 more source

