Results 111 to 120 of about 1,271,225 (346)

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

open access: yesAdvanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño   +5 more
wiley   +1 more source

Development of experimental alloxan model of diabetes mellitus

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2017
Background. One of the main causes that lead to the disability of diabetic patients is diabetic retinopathy (DR). The relevance of the problem of DR necessitates the development of optimal experimental models on experimental animals to find effective ...
V.V. Semenko   +2 more
doaj   +1 more source

A Review of the Anti-diabetic Activity of Andrographis Paniculata (Burm. F.) Nees Based In-vivo Study [PDF]

open access: yes, 2015
Diabetes mellitus (DM) is ricing nowadays. DM is a metabolic deasease characterized by increasing of glucose blood level for prolonged time. Patient with DM must take medicine for lowering glucose levels in whole life.
Harimurti, S. (Sabtanti)   +1 more
core  

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes [PDF]

open access: yes, 2015
Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation.
Bertolini, Camilla   +10 more
core   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

open access: yesAdvanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao   +6 more
wiley   +1 more source

Identification and analysis of the expression of genes, involved in insulin signals transmission in the development of experimental type 2 diabetes mellitus

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Type 2 diabetes mellitus is a significant concern due to its high prevalence and impact on global health. Ongoing scientific research aims to enhance our understanding of the mechanisms involved in the development and progression of diabetes and devise ...
T. V. Ivanenko, А. V. Vynokurova
doaj   +1 more source

Electrocardiographic manifestation of cardiac repolarization dispersion [PDF]

open access: yes, 2019
Alterations of repolarization heterogeneity in the heart have been established as anAlterations of repolarization heterogeneity in the heart have been established as ...
Sedova Ksenia
core  

The glycemic elemental profile of trichosanthes dioica: a LIBS-based study [PDF]

open access: yes, 2010
The scientific evaluation of the antidiabetic efficacy of aqueous extract of Trichosanthes dioica fruits on streptozotocin-induced diabetic rats is being presented. The graded doses of the extract, viz., 500, 750, 1,000, and 1,250 mg/kg body weight (bw),
Bicanic, D.D.   +4 more
core   +2 more sources

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

open access: yesAdvanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo   +14 more
wiley   +1 more source

OXIDATIVE STRESS CARACTERIZATION IN STREPTOZOTOCIN-DIABETIC WISTAR RATS

open access: yesVitae, 2009
Diabetes is a chronic metabolic disease. Numerous studies have demonstrated that diabetes mellitus is associated to free radicals increase derived from oxygen and to the organism potential antioxidant decrease generating oxidative damage of some cell ...
Ángela C. MORA H.   +2 more
doaj  

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