Results 1 to 10 of about 641,645 (355)

Experimental Diabetes Mellitus in Different Animal Models [PDF]

Journal of Diabetes Research, 2016
Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo.
Amin Al-awar, Krisztina Kupai, Médea Veszelka, Gergő Szűcs, Zouhair Attieh, Zsolt Murlasits, Szilvia Török, Anikó Pósa, Csaba Varga   +8 more
doaj   +7 more sources

Experimental Approaches to Diabetes Mellitus

Eurasian Journal of Medicine, 2022
One of the most common health problems today, diabetes is a serious, chronic, and complex disease characterized by high blood glucose levels. Nowadays, experimental diabetes models are being developed to study existing diabetes in depth, to improve diabetes medications, or to develop new medications.
Muhammed Yayla, Damla Binnetoğlu
doaj   +3 more sources

Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus. [PDF]

PLoS One, 2019
BackgroundDiabetic cardiomyopathy (DM CMP) is defined as cardiomyocyte damage and ventricular dysfunction directly associated with diabetes independent of concomitant coronary artery disease or hypertension.
Ahn, Jinhee, Bae, Sun Sik, Cha, Kwang Soo, Choi, Jung Hyun, Hong, Taek Jong, Kim, Sang Sik, Lee, Han Cheol, Lee, Hye Won, Lee, Min Young, Lee, Sun Ju, Lovett, David H, Oh, Jun-Hyok, Park, Jin-Sup, Park, Mi Wha, Shin, Nari, Song, Sang Heon   +15 more
core   +3 more sources

Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect. [PDF]

Antioxidants (Basel), 2021
Rodríguez-Pérez MD, López-Villodres JA, Arrebola MM, Martín-Aurioles E, Fernández-Prior Á, Bermúdez-Oria A, Ríos MC, De La Cruz JP, González-Correa JA.   +8 more
europepmc   +3 more sources

Effect of extracts of Geranium ayavacense W. (Pasuchaca) on glycemia on rats with experimental diabetes mellitus

Revista Peruana de Medicina Experimental y Salud Pública, 2014
Objectives. To determine if the lyophilized aqueous extract of Geranium ayavacense (Pasuchaca) has any effect on glycemia in rats with experimental diabetes mellitus. Materials and methods. Experimental diabetes was induced with alloxan. Rats included in
José Aranda-Ventura, Jorge Villacrés, Rosario Mego, Henry Delgado   +3 more
doaj   +3 more sources

Beneficial Effects of Grape Pomace Extract on Hyperglycemia, Dyslipidemia, and Oxidative Stress in Experimental Diabetes Mellitus. [PDF]

Molecules
Sabadashka M, Chala D, Chrzanowski G, Cichoński J, Sybirna N.   +4 more
europepmc   +3 more sources

Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway

Frontiers in Cell and Developmental Biology, 2020
Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has been demonstrated to alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism has not been fully elucidated.
Yunyun Fang, Linlin Ji, Chaoyu Zhu, Yuanyuan Xiao, Jingjing Zhang, Junxi Lu, Jun Yin, Jun Yin, Li Wei   +8 more
doaj   +1 more source

Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Бюллетень сибирской медицины, 2022
Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy.The aim of the study was to analyze the levels of insulin-like growth factors (IGFs), their carrier proteins (
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. K. Trepitaki, N. D. Cheryarina, I. M. Kotieva, M. I. Morozova   +9 more
doaj   +1 more source

Speckle-tracking echocardiography combined with imaging mass spectrometry assesses region-dependent alterations [PDF]

, 2020
Left ventricular (LV) contraction is characterized by shortening and thickening of longitudinal and circumferential fibres. To date, it is poorly understood how LV deformation is altered in the pathogenesis of streptozotocin (STZ)-induced type 1 diabetes
Dong, Fengquan, El-Shafeey, Muhammad, Grune, Jana, Hegemann, Niklas, Kintscher, Ulrich, Klein, Oliver, Kuebler, Wolfgang M., Lin, Jie, Linthout, Sophie Van, Pappritz, Kathleen, Tschöpe, Carsten   +10 more
core   +1 more source

Vascular Reactivity in Experimental Diabetes Mellitus [PDF]

Circulation Research, 1964
Vascular reactivity was examined in vessels of the perfused hindquarters of alloxan diabetic and control rats. A significant increase was noted in responsiveness of the diabetic animals to intra-arterial injection of epinephrine, norepinephrine, and synthetic angiotensin.
MICHAEL J. BRODY, ROBERT L. DIXON, Richard A. Shaffer   +2 more
openaire   +2 more sources