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Experimental Approaches to Diabetes Mellitus

Eurasian Journal of Medicine, 2022
One of the most common health problems today, diabetes is a serious, chronic, and complex disease characterized by high blood glucose levels. Nowadays, experimental diabetes models are being developed to study existing diabetes in depth, to improve diabetes medications, or to develop new medications.
Muhammed Yayla, Damla Binnetoğlu
doaj   +3 more sources

Experimental Diabetes Mellitus in Different Animal Models [PDF]

Journal of Diabetes Research, 2016
Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo.
Amin Al-awar, Krisztina Kupai, Médea Veszelka, Gergő Szűcs, Zouhair Attieh, Zsolt Murlasits, Szilvia Török, Anikó Pósa, Csaba Varga   +8 more
doaj   +6 more sources

How to create an experimental diabetes mellitus model? [PDF]

Pharmacia, 2023
Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Early treatment is very important in terms of preventing diabetes-related late complications with high treatment costs and increasing the patient’s quality of life.
Rabia Edibe Parlar Köprülü
doaj   +6 more sources

Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus

Life, 2022
Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM).
Hande Yapislar, Ebru Haciosmanoglu, Turkan Sarioglu, Sevgin Degirmencioglu, Ibrahim Sogut, Michael Poteser, Cem Ekmekcioglu   +6 more
doaj   +3 more sources

Experimental Gestational Diabetes Mellitus Prolongs Post-Incisional Mechanical Hypersensitivity and Increases Cutaneous Neuro-Immune Markers in Adult Female Offspring [PDF]

Journal of Pain Research
Carlos A Cantú-Cepeda, Jaira Villarreal-Salcido, Cecilia Esther Elizondo-Martinez, Juan Antonio Vazquez-Mora, Arisai Martínez-Martínez, Rosa Issel Acosta-González, Juan Miguel Jiménez-Andrade, Enriqueta Muñoz-Islas Laboratory of Pharmacology ...
Cantú-Cepeda CA, Villarreal-Salcido J, Elizondo-Martinez CE, Vazquez-Mora JA, Martínez-Martínez A, Acosta-González RI, Jiménez-Andrade JM, Muñoz-Islas E   +7 more
doaj   +2 more sources

Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway

Frontiers in Cell and Developmental Biology, 2020
Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has been demonstrated to alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism has not been fully elucidated.
Yunyun Fang, Linlin Ji, Chaoyu Zhu, Yuanyuan Xiao, Jingjing Zhang, Junxi Lu, Jun Yin, Jun Yin, Li Wei   +8 more
doaj   +1 more source

Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Бюллетень сибирской медицины, 2022
Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy.The aim of the study was to analyze the levels of insulin-like growth factors (IGFs), their carrier proteins (
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. K. Trepitaki, N. D. Cheryarina, I. M. Kotieva, M. I. Morozova   +9 more
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Avaliação de parâmetros de cicatrização no cólon de ratos diabéticos sem agressão cirúrgica [PDF]

Acta Cirúrgica Brasileira, 2004
OBJETIVO: Existem poucos estudos na literatura utilizando parâmetros de cicatrização em animais diabéticos antes da agressão cirúrgica e nenhum estudo no colon.
Erika Veruska Paiva Ortolan, César Tadeu Spadella, José Lúcio Martins Machado, Shoiti Kobayasi   +3 more
doaj   +1 more source

Pancreatic islet isolation by mechanical-enzymatic separation, stationary collagenase digestion and dextran discontinuous density gradient purification: experimental study in dogs Isolamento das ilhotas pancreáticas pela separação mecânica-enzimática digestão estacionária com colagenase e purificação com gradiente de densidade descontínua de dextran: estudo experimental em cães

Acta Cirúrgica Brasileira, 2002
The prospects for allotransplantation of pancreatic islets in man depend on the development of methods that provide sufficient quantities of pancreatic islets from a single donor, which are capable, when transplanted, of achieve the normalization of ...
Jaques Waisberg, Heloísa Prado Soares, Luís Gustavo Altieri, Osíris Ramaciotti, Manlio Basilio Speranzini   +4 more
doaj   +1 more source

Vascular Reactivity in Experimental Diabetes Mellitus [PDF]

Circulation Research, 1964
Vascular reactivity was examined in vessels of the perfused hindquarters of alloxan diabetic and control rats. A significant increase was noted in responsiveness of the diabetic animals to intra-arterial injection of epinephrine, norepinephrine, and synthetic angiotensin.
MICHAEL J. BRODY, ROBERT L. DIXON, Richard A. Shaffer   +2 more
openaire   +2 more sources