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Experimental Approaches to Diabetes Mellitus
The Eurasian Journal of Medicine, 2023 One of the most common health problems today, diabetes is a serious, chronic, and complex disease characterized by high blood glucose levels. Nowadays, experimental diabetes models are being developed to study existing diabetes in depth, to improve diabetes medications, or to develop new medications.
Muhammed Yayla, Damla Binnetoğlu
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Vascular Reactivity in Experimental Diabetes Mellitus [PDF]
Circulation Research, 1964 Vascular reactivity was examined in vessels of the perfused hindquarters of alloxan diabetic and control rats. A significant increase was noted in responsiveness of the diabetic animals to intra-arterial injection of epinephrine, norepinephrine, and synthetic angiotensin.
MICHAEL J. BRODY +2 more
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Experimental models of diabetes mellitus [PDF]
Serbian Journal of Experimental and Clinical Research, 2011 Early studies on pancreatectomised dogs confirmed the central role of the pancreas in the homeostasis of glycemia and resulted in the discovery of insulin. Today, hundreds of different animal models are used in experimental studies of diabetes. The aim of this review is to present experimental models of type 1 and type 2 diabetes. In preparing for this
Jelena Pantic +2 more
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Experimental Diabetes Mellitus in Different Animal Models [PDF]
Journal of Diabetes Research, 2016 Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels ...
Amin Al-awar +8 more
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Glomerular hemodynamics in experimental diabetes mellitus
Kidney International, 1981 Micropuncture studies were performed in three groups of euvolemic male Munich-Wistar rats: 8 control rats, 7 severely hyperglycemic rats made diabetic with streptozotocin (60 mg/kg, i.v.), and 6 moderately hyperglycemic rats made diabetic by the same method but given 2 U of NPH insulin daily.
Hostetter, Thomas H. +2 more
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VARIOUS FORMS OF EXPERIMENTAL DIABETES AND THEIR SIGNIFICANCE FOR DIABETES MELLITUS [PDF]
JAMA: The Journal of the American Medical Association, 1910 In the short time allotted in this symposium to the study of experimental diabetes or glycosuria, I shall not of course attempt to give any general review of all the experimental conditions which may cause reducing substances to appear in the urine. It will be more profitable to devote the greater part of my time to a study of the simplest and best ...
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How to create an experimental diabetes mellitus model?
Pharmacia, 2023 Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Early treatment is very important in terms of preventing diabetes-related late complications with high treatment costs and increasing the patient’s quality of life. In addition to investigating the pathophysiology of the disease studied, animal experiments pave the way for new ...
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Renal hypertrophy in experimental diabetes mellitus
Kidney International, 1983 The kidney changes seen in rats shortly after the induction of experimental diabetes were reviewed: Kidney weight increases by 15 to 20% during the first 4 to 5 days of diabetes and by 70 to 90% after some weeks. GFR increases after a lag-time of some days in parallel to kidney weight.
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Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetes Mellitus
Journal of Agricultural and Food Chemistry, 2017 The aim of the study was to analyze the possible neuroprotective effect of hydroxytyrosol (HT) in diabetic animals in a model of hypoxia-reoxygenation. Rats (10 animals/group) were distributed in five groups: nondiabetic rats, control diabetic rats (DR), and DR rats treated for 2 months with 1, 5, or 10 mg/kg/day po HT.
Reyes, J.J. +8 more
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Effects of Caffeine and Lycopene in Experimentally Induced Diabetes Mellitus
Pancreas, 2016 Diabetes mellitus (DM) is a global epidemic with increasing prevalence. The disease is chronic in nature, and patients must use antidiabetic drugs or insulin during their lifespan. Because of the difficulty of using injectable insulin preparations, patients and practitioners prefer to use oral antidiabetic drugs for prophylaxis and treatment. There are,
Ozmen, O. +4 more
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