Results 241 to 250 of about 1,168,236 (313)

Trajectories of Health-Related Quality of Life and HbA1c Values of Children and Adolescents With Diabetes Mellitus Type 1 Over 6 Months: A Longitudinal Observational Study. [PDF]

Front Pediatr, 2019
Fischer KI, Fischer FH, Barthel D, Otto C, Thyen U, Klein M, Walter O, Ravens-Sieberer U, Rose M, Nolte S.   +9 more
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Prevalence of markers of celiac disease in Colombian children with diabetes mellitus type 1. [PDF]

Colomb Med (Cali), 2018
Velasco-Benítez CA, Ruíz-Extremera Á, Matallana-Rhoades AM, Giraldo-Lora SC, Ortíz-Rivera CJ.   +4 more
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Coexistence of diabetes mellitus type 1 with diffuse systemic sclerosis - case report and literature review. [PDF]

Reumatologia, 2017
Wielosz E, Kurowska M, Suszek D, Majdan M.   +3 more
europepmc   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Investigation of Metformin Contamination in Horses: Implications for Environmental Exposure and Doping Control

Drug Testing and Analysis, EarlyView.
The widespread use of metformin in human medicine coupled with the detection of metformin in blood and urine samples collected from racehorses has raised concern about the potential for exposure from contaminated stalls. This study describes blood and urine concentrations in horses following intentional exposure of horses to metformin contaminated ...
Megan E. Jacobs, Jeff Blea, Michael Hardy, Daniel S. McKemie, Megan Traynham, Heather K. Knych   +5 more
wiley   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Feasibility and Preliminary Efficacy of a Guided Self‐Help Digital Intervention for Adults With Food Insecurity, Recurrent Binge Eating, and Type 2 Diabetes Mellitus: A Pilot Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Food insecurity is increasingly linked to binge eating and weight‐related health issues like type 2 diabetes mellitus, but no eating disorder interventions have been tested among individuals with food insecurity. We conducted a single‐arm pilot test of FoodSteps‐FI, a guided self‐help digital intervention for binge eating adapted for
Andrea K. Graham, Rebecca L. Flynn, Isabel R. Rooper, Chidiebere Azubuike, Lindsay D. Lipman, Adrian Ortega, Leah M. Parsons, Graham C. Miller, Damien Lekkas, Jennifer E. Wildes   +9 more
wiley   +1 more source