Results 141 to 150 of about 423,317 (260)

Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model

Annals of Neurology, EarlyView.
Objective The optimal treatment for distal medium vessel occlusion (DMVO) stroke remains uncertain, and evidence comparing endovascular therapy (EVT) with medical management (MM) is limited. We aimed to develop and validate a predictive modeling tool to assess individual treatment benefit in DMVO stroke using explainable counterfactual treatment ...
Mohamed F. Doheim, Mahmoud H. Mohammaden, Hend Abdelhamid, Marta Olive‐Gadea, Marc Rodrigo‐Gisbert, Manuel Requena, Johanna T. Fifi, James E. Siegler, Santiago Ortega‐Gutierrez, Mohamad Abdalkader, Ali Alaraj, Wei Hu, Thanh N. Nguyen, Diogo C. Haussen, Raul G. Nogueira   +14 more
wiley   +1 more source

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

Annals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura, Frederik J. Steyn, Shuhei Kobashi, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Robert D. Henderson, Shyuan T. Ngo, Makoto Urushitani   +8 more
wiley   +1 more source

Translating Biomedical Research to Medical Devices: A Practical Guide and the Arteriovenous Graft Case Study

Advanced NanoBiomed Research, EarlyView.
Despite significant advances, most academic research fails to result in medical products that benefit patients. This guide shares five key steps to help researchers close that gap: set clear goals, test thoroughly, protect ideas, build diverse teams, and partner with industry.
Cristina Oldani, Nina Bono, Alice Caldiroli, Stefania Adele Riboldi, Gabriele Candiani   +4 more
wiley   +1 more source

Effectiveness of Nurse-Led Intervention on Prevention of Type 2 Diabetes among Prediabetic Employees of Steel Plant in Odisha: A Pilot Study.

J Pharm Bioallied Sci
Jena N, Therese AM, Malarvizhi, Jasmine J, Kumar S.   +4 more
europepmc   +1 more source

18β-Glycyrrhetinic acid-loaded silver nanoparticles mitigate neuroinflammation and endoplasmic reticulum stress in the brain tissue of diabetic rats. [PDF]

Iran J Basic Med Sci
Parlak SN, Yakut S, Kara A, Demi̇r Ö, Özbek Şebi̇n S.   +4 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Noninvasive Glucose Detection with Biodegradable Electrodes from Rice Starch Functionalized with a Carbon Quantum Dot/Nickel Oxide Nanocomposite

Analysis &Sensing, EarlyView.
The graphical abstract shows an eco‐friendly approach to fabricating a biodegradable electrochemical sensor. Carbon quantum dot/nickel oxide (CQD/NiO) nanocomposites are synthesized using Aloe arborescens leaf extract, which served as a natural reducing and stabilizing agent.
Nokwanda Ngema, Ryal Atson, Orlette Mkhari, Mahabubur Rahman Chowdhury   +3 more
wiley   +1 more source

(TCRαβ⁺) Double-Negative T Cells in Type 1 Diabetes Mellitus. [PDF]

Cells
Poddighe D, Mussayeva A, Dossybayeva K, Zhubanova G, Galiyeva D, Le KL, Tanko MN.   +6 more
europepmc   +1 more source

A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus

Arthritis &Rheumatology, EarlyView.
Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progression to SLE. Treatment of ILE may reduce symptoms, severity, and incidence of SLE.
Nancy J. Olsen, Duanping Liao, Judith A. James, Joel M. Guthridge, Cristina Arriens, Diane Kamen, Mariko Ishimori, Daniel J. Wallace, Christopher Striebich, Sonali Narain, Benjamin F. Chong, Fan He, Eric W. Schaefer, Vernon M. Chinchilli, David R. Karp   +14 more
wiley   +1 more source

Maternal gestational diabetes mellitus leads to adverse growth patterns and disease risk in offspring in vivo: evidence from cross-generational effects on gut microbiota. [PDF]

BMC Microbiol
Yao T, Xiong Y, Hu Q, Chen Y, Li D, Yan J, Yang J, Wang Y, Cao H, Zhang F, Zhuang R, Sun J.   +11 more
europepmc   +1 more source