Results 111 to 120 of about 111,544,121 (255)

PHARMACOLOGICAL NEUROPROTECTION OF TYPE 1 DIABETES MELLITUS

Ukrainian Scientific Medical Youth Journal, 2016
Type 1 diabetes mellitus (DM) - one of the most common diseases of modern endocrinology. The growing number of sick children, emergence of chronic diseases and high percentage of disability determine the severity of the problem. Diabetic neuropathy (DN),
O. Fitsner, M. Khaitovych
doaj  

Association of RPS26 gene polymorphism with different types of diabetes in Chinese individuals

Journal of Diabetes Investigation
Aims/Introduction Different types of diabetes show distinct genetic characteristics, but the specific genetic susceptibility factors remain unclear. Our study aimed to explore the associations between the ribosomal protein S26 (RPS26) gene rs1131017 ...
Rong Song, Lingxiang Xie, Jin Ding, Yan Chen, Hailan Zou, Haipeng Pang, Yiman Peng, Ying Xia, Zhiguo Xie, Xia Li, Yang Xiao, Zhiguang Zhou, Jingyi Hu   +12 more
doaj   +1 more source

Bioleptin as a useful marker of metabolic status in children with diabetes mellitus type 1. [PDF]

Front Endocrinol (Lausanne), 2023
Jakubek-Kipa K, Galiniak S, Łagowska K, Krupa I, Ludwin A, Tabarkiewicz J, Mazur A.   +6 more
europepmc   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Hepatic insulin synthesis increases in rat models of diabetes mellitus type 1 and 2 differently. [PDF]

PLoS One, 2023
Abidov M, Sokolova K, Danilova I, Baykenova M, Gette I, Mychlynina E, Aydin Ozgur B, Gurol AO, Yilmaz MT.   +8 more
europepmc   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Incidence of insulin-treated diabetes in Australia 2000-2011 [PDF]

, 2014
Australia\u27s rate of incidence of insulin-treated diabetes has remained stable over the last decade, with between 10 and 12 new cases per 100,000 population per year.

core  

DIABETES MELLITUS IN PATIENTS FROM BURYAT POPULATION

Acta Biomedica Scientifica, 2013
The paper considers specific features of type 1 Diabetes Mellitus in patients from Buryat populations. Characteristics of the incidence and prevalence of type 1 Diabetes Mellitus in patients of Buryat nationality are presented. Clinicalfeatures of type 1
T. P. Bardymova, L. I. Kolesnikova
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