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Acatalasemia and type 2 diabetes mellitus
Orvosi Hetilap, 2015The catalase enzyme decomposes the toxic concentrations of hydrogen peroxide into oxygen and water. Hydrogen peroxide is a highly reactive small molecule and its excessive concentration may cause significant damages to proteins, deoxyribonucleic acid, ribonucleic acid and lipids. Acatalasemia refers to inherited deficiency of the catalase enzyme.
László Góth +2 more
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Pathogenesis of Type 2 Diabetes Mellitus
Archives of Medical Research, 2005The pathological sequence for type 2 diabetes is complex and entails many different elements that act in concert to cause that disease. This review proposes a sequence of events and how they interact by a careful analysis of the human and animal model literature.
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Genes and type 2 diabetes mellitus
Current Diabetes Reports, 2008In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity.
Leif Groop, Valeriya Lyssenko
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Type 2 diabetes mellitus in adolescents
Current Opinion in Pediatrics, 2000Type 2 diabetes mellitus, a significant cause of adult morbidity and mortality, is being diagnosed more frequently in children and adolescents. Genetic predisposition and environmental factors are important determinants for the expression of this disease.
M J Mansfield, S T Callahan
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Lixisenatide for type 2 diabetes mellitus
Expert Opinion on Investigational Drugs, 2011Type 2 diabetes mellitus (T2DM) is an increasing health problem worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists are an expanding drug class that target several of the pathophysiological traits of T2DM. Lixisenatide is a GLP-1 receptor agonist in development for once-daily treatment of T2DM.Pharmacological, preclinical and clinical evidence
Christensen, Mikkel +3 more
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Dyslipidemia in type 2 diabetes mellitus
Current Diabetes Reports, 2007Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is now recognized as a risk equivalent for coronary heart disease. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholesterol, and small dense low-density ...
Frederick F. Samaha, Ramprasad Gadi
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1999
Type 2 diabetes mellitus is a disease characterized by both abnormalities in insulin secretion and target-tissue resistance to the actions of insulin. Therefore, it is not surprising that replacement therapy with insulin alone is not sufficient to control blood glucose and many of the other metabolic abnormalities in patients with type 2 diabetes ...
Rubin Bressler, David Johnson
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Type 2 diabetes mellitus is a disease characterized by both abnormalities in insulin secretion and target-tissue resistance to the actions of insulin. Therefore, it is not surprising that replacement therapy with insulin alone is not sufficient to control blood glucose and many of the other metabolic abnormalities in patients with type 2 diabetes ...
Rubin Bressler, David Johnson
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Genetics of type 2 diabetes mellitus
Diabetes Research and Clinical Practice, 2005The clinical picture of type 2 diabetes mellitus (T2DM) is formed by impairment in insulin secretion and resistance to insulin action. As a result of intensive efforts of the scientists around the world mutations and polymorphisms in a number of genes were linked with monogenic and polygenic forms of T2DM.
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Genes and Type 2 Diabetes Mellitus
Archives of Medical Research, 2005Type 2 diabetes (T2DM) comprises a group of entities with different genetic causes. In most patients, T2DM results from alterations of various genes, each having a partial and additive effect. The inheritance pattern is thus complex, and environmental factors play an important role in favoring or delaying the expression of the disease.
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