Results 41 to 50 of about 1,643,238 (355)
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
New England Journal of Medicine, 2013 BACKGROUND The cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear.
B. Scirica +17 more
semanticscholar +1 more source
TREATMENT OF TYPE 2 DIABETES MELLITUS
Medical Clinics of North America, 1998 Although most patients with type 2 diabetes mellitus can be initially managed with diet and exercise alone, most eventually require at least oral agents if not insulin to maintain glycemic control. Appropriate therapeutic regimens may be difficult to design, given the diversity of drugs available for clinical use.
Feinglos, M, Bethel, M
openaire +3 more sources
The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
International Journal of Molecular SciencesObesity or excessive weight gain is identified as the most important and significant risk factor in the development and progression of type 2 diabetes mellitus (DM) in all age groups.
Preethi Chandrasekaran, Ralf Weiskirchen
semanticscholar +1 more source
Journal of Diabetes Investigation, 2020 Aims/Introduction Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus is ...
Maki Yokoyama +10 more
doaj +1 more source
Cytogenetic study of type 2 diabetes mellitus
Wasit Journal for Pure Sciences, 2022 Type 2 of diabetic mellitus (DM) is characterized by chronic hyperglycemia with abnormalities of fat and protein metabolism resulting from defects in insulin secretion, insulin action or both.
Zafir Hassan Ghali , Noor Jamal Hussein
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Dyslipidemia in Type 2 Diabetes Mellitus
Journal of Islamic International Medical College, 2021 Objective: To determine the correlation of plasma glucose levels with lipid profile in type 2 Diabetes Mellitus (T2DM). Study Design: Case control study.
Mehnaz Khattak, Asif Nawaz, Jawwad Anis Khan, Umme Farwa
doaj
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source