Results 1 to 10 of about 583,851 (285)

Molecular Mechanism of Naringenin Against High-Glucose-Induced Vascular Smooth Muscle Cells Proliferation and Migration Based on Network Pharmacology and Transcriptomic Analyses [PDF]

Frontiers in Pharmacology, 2022
Although the protective effects of naringenin (Nar) on vascular smooth muscle cells (VSMCs) have been confirmed, whether it has anti-proliferation and anti-migration effects in high-glucose-induced VSMCs has remained unclear.
Wenjun He, Wenjun He, Wenjun He, Yanming Wang, Yanming Wang, Yanming Wang, Rui Yang, Rui Yang, Rui Yang, Huihui Ma, Huihui Ma, Huihui Ma, Xuqing Qin, Xuqing Qin, Xuqing Qin, Meijuan Yan, Meijuan Yan, Meijuan Yan, Yi Rong, Yi Rong, Yi Rong, Yufang Xie, Yufang Xie, Yufang Xie, Li Li, Junqiang Si, Junqiang Si, Junqiang Si, Xinzhi Li, Xinzhi Li, Xinzhi Li, Ketao Ma, Ketao Ma, Ketao Ma   +33 more
doaj   +3 more sources

The oxidative modification of von Willebrand factor is associated with thrombotic angiopathies in diabetes mellitus. [PDF]

PLoS ONE, 2013
The thrombogenic activity of Von Willebrand factor (VWF) is proportional to its molecular size and inversely related to its proteolysis by ADAMTS-13. Oxidation of VWF severely impairs its proteolysis by the metalloprotease.
Laura Oggianu, Stefano Lancellotti, Dario Pitocco, Francesco Zaccardi, Paola Rizzo, Francesca Martini, Giovanni Ghirlanda, Raimondo De Cristofaro   +7 more
doaj   +2 more sources

Vascular complications of diabetes mellitus worldwide and in Russia: The path of 100 years. A review [PDF]

Терапевтический архив, 2023
With the discovery and introduction of insulin, the "palette" of life-threatening conditions for patients with diabetes mellitus has changed dramatically: from diabetic coma of the "pre-insulin era" to severe vascular complications in the modern period ...
Marina V. Shestakova, Anastasia S. Severina   +1 more
doaj   +2 more sources

Infections in patients with diabetes mellitus: A review of pathogenesis

Indian Journal of Endocrinology and Metabolism, 2012
In general, infectious diseases are more frequent and/or serious in patients with diabetes mellitus, which potentially increases their morbimortality.
Juliana Casqueiro, Janine Casqueiro, Cresio Alves   +2 more
doaj   +2 more sources

Diabetic angiopathy and angiogenic defects [PDF]

Fibrogenesis & Tissue Repair, 2012
Abstract Diabetes is one of the most serious health problems in the world. A major complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this review, we focus on angiogenesis abnormalities in diabetic complications and discuss its benefits and drawbacks as a therapeutic target
Keizo Kanasaki, Daisuke Koya, Munehiro Kitada, Ling Xu   +3 more
openaire   +5 more sources

Treatment of erectile dysfunction by intracavernosal administration of mesenchymal stem cells in patients with diabetes mellitus [PDF]

International Brazilian Journal of Urology
Erectile dysfunction is observed in about 50% of men. It has been found that diabetes mellitus increases its prevalence to 19-86.3%, necessitating attention to a therapeutic strategy.
Yerbol Iskakov, Rustam Omarbayev, Rinat Nugumanov, Timur Turgunbayev, Yerkebulan Yermaganbetov   +4 more
doaj   +2 more sources

Role of advanced glycation end products related to the onset of diabetic kidney disease complications

Clinical and Biomedical Research, 2017
Advanced glycation end products are known to play an important role in the diabetes complications, such as diabetic nephropathy. Most known pathways of diabetic complications involve oxidative stress, that have pivotal role in cell dysfunction onset and ...
Maria Luiza Almeida de Paula, Ana Marina Rodrigues Villela, Mauricio Massucati Negri, Salim Kanaan, Luciene de Carvalho Cardoso Weide   +4 more
doaj   +4 more sources

Endothelial dysfunction and pathogenesis of diabetic angiopathy [PDF]

Cardiovascular Research, 1997
To review, from the clinical perspective, the contribution of dysfunction of the vascular endothelium to the pathogenesis of diabetic micro- and macroangiopathy.Available data indicate that endothelial dysfunction in diabetes complicated by micro- or macroalbuminuria (renal microangiopathy) is generalised. The close linkage between microalbuminuria and
A. J. M. Donker, Victor W.M. van Hinsbergh, J. Lambert, Coen D.A. Stehouwer   +3 more
openaire   +5 more sources

Assessment of lower extremities ischemic disease by thallium 201 perfusion scintigraphy in patients with diabetic angiopathy [PDF]

Vojnosanitetski Pregled, 2011
Background/Aim. Tibial perfusion in diabetic microangiopathy is considered to be a diagnostic problem. A special place in quantifying muscle microcirculatory perfusion belongs to thallium 201 muscle perfusion scintigraphy (201Tl PS).
Čizmić Milica, Pucar Dragan, Zoranović Uroš   +2 more
doaj   +3 more sources

Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications [PDF]

Adipocyte, 2014
Diabetes leads to complications in select organ systems primarily by disrupting the vasculature of the target organs. These complications include both micro-(cardiomyopathy, retinopathy, nephropathy, and neuropathy) and macro-(atherosclerosis ...
Khan, Zia A., Piccinin, Meghan A.
core   +3 more sources