Results 41 to 50 of about 308,698 (194)

Clinical decision support software for diabetic foot risk stratification: development and formative evaluation

Journal of Foot and Ankle Research, 2015
Background Identifying people at risk of developing diabetic foot complications is a vital step in prevention programs in primary healthcare settings. Diabetic foot risk stratification systems predict foot ulceration. The aim of this study was to explore
Deborah E. Schoen, David G. Glance, Sandra C. Thompson   +2 more
doaj   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

EVALUATION OF THE LEVELS OF FIBROBLAST GROWTH FACTOR (FGF-23) AND INFLAMMATION MARKERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE

Juvenis Scientia, 2020
Recently, inflammatory and regulatory mechanisms that are involved in the onset and progression of angiopathies in diabetes mellitus (DM), including diabetic kidney disease (DKD), have been studied.
V.M. Vasilkova, T.V. Mokhort, V.K. Bayrasheva, L.E. Korotaeva, Yu.I. Yarets, О.N. Shestovets, Ya.A. Borovets, E.P. Naumenko   +7 more
doaj  

Modifiable Risk Factors and Hearing Loss: The National Health and Nutrition Examination Survey 1999–2020

Clinical Otolaryngology, EarlyView.
ABSTRACT Objective To explore the associations between major modifiable risk factors and hearing loss. Methods This serial cross‐sectional study was conducted within the National Health and Nutrition Examination Survey 1999–2020 in the United States. Associations were assessed using modified Poisson regression and within‐sample population attributable ...
Yulu Zheng, Tingting Li, Zhiyuan Wu, Yahong Zhu, Zheng Guo, Xingang Li   +5 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

EFFECT OF COMPLEX HOMEOPATHIC DRUG CONTAINING COENZYME Q ON PARAMETERS OF OXIDATIVE STRESS AND HEMODYNAMICS IN EXPERIMANTAL DIABETES MELLITUS

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study the influence of complex homeopathic drug ubichinon compositum on hemodynamics, Na,K-ATPase activity, parameters of oxidative stress and serum nitric oxide (NO) metabolites concentration in experimental diabetes mellitus.Materials and ...
S. G. Dzugkoev, V. A. Metelskaya, I. V. Mozhaeva, F. S. Dzugkoeva   +3 more
doaj   +1 more source

Optimization of bioactive compounds extraction from Rosa canina L. pseudofruit through the action of two hydrolytic enzyme preparations

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 10, Page 1954-1967, October 2026.
Abstract BACKROUND The pseudo‐fruit of Rosa canina L. is a rich source of bioactive compounds with antioxidant, anti‐inflammatory, anti‐cancer, anti‐diabetic, anti‐aging, and antimicrobial activities. The aim of the present study is the optimization of a green process based on the action of two hydrolytic enzyme preparations, namely Pectinex® Ultra ...
Zafeiria Lemoni, Styliani Kalantzi, Theopisti Lymperopoulou, Andromachi Tzani, Georgios Stavropoulos, Anastasia Detsi, Diomi Mamma   +6 more
wiley   +1 more source

Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION While both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestigated. METHODS This cross‐sectional study included 650 participants (149 AD, 276 CSVD, and 225 cognitively unimpaired individuals).
Ziyi Zhang, Le Cao, Peng Liu, Shiyun Yang, Yuying Yan, William Robert Kwapong, Ying He, Mingyuan Yang, Hang Wang, Youjie Wang, Zijuan Feng, Jingyu Zhou, Ming Liu, Peng Lei, Bo Wu, Shuting Zhang   +15 more
wiley   +1 more source

MCH‐Guard: Multimodal machine learning framework for risk stratification of cerebral microhemorrhage risk in the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti‐amyloid therapy safety due to amyloid‐related imaging abnormalities with hemosiderin deposition (ARIA‐H) risk. We developed MCH‐Guard, a multimodal machine‐learning framework, to stratify MCH risk for Alzheimer's Disease Neuroimaging Initiaitive (ADNI ...
Alper Gel, Eliana Phillips, Isabella Hausle, Pamela Thropp, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
wiley   +1 more source

Global Epidemiology of Diabetic Foot: A Systematic Review and Meta‐Analysis

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Introduction Diabetic foot (DF) disease, including ulcerations, amputations, and infections, represents a major cause of morbidity and mortality in individuals with diabetes mellitus (DM). Despite their substantial clinical, social, and economic burden, robust global epidemiological estimates remain limited due to fragmented evidence and ...
Massimo Carollo, Ylenia Ingrasciotta, Salvatore Crisafulli, Francesco Maccarrone, Daniela Pellegrino, Alberto Francescon, Edoardo Mannucci, Andrea Fontana, Gianluca Trifirò   +8 more
wiley   +1 more source