Results 1 to 10 of about 1,112,461 (309)

Cardiovascular Autonomic Neuropathy in Type 1 Diabetes Is Associated With Disturbances in TCA, Lipid, and Glucose Metabolism

Frontiers in Endocrinology, 2022
IntroductionDiabetic cardiovascular autonomic neuropathy (CAN) is associated with increased mortality and morbidity. To explore metabolic mechanisms associated with CAN we investigated associations between serum metabolites and CAN in persons with type 1
Christian S. Hansen, Tommi Suvitaival, Simone Theilade, Simone Theilade, Simone Theilade, Ismo Mattila, Maria Lajer, Kajetan Trošt, Linda Ahonen, Tine W. Hansen, Cristina Legido-Quigley, Peter Rossing, Peter Rossing, Tarunveer S. Ahluwalia, Tarunveer S. Ahluwalia   +14 more
doaj   +1 more source

Novel topical allogeneic bone-marrow-derived mesenchymal stem cell treatment of hard-to-heal diabetic foot ulcers: a proof of concept study

Stem Cell Research & Therapy, 2022
Aim The aim of this study was to investigate safety of treating diabetic foot ulcers with a topically administered mesenchymal stem cell product. Method Individuals with diabetes, peripheral neuropathy, toe blood pressure > 39 mmHg and non-infected foot ...
Jonas Askø Andersen, Anne Rasmussen, Marie Frimodt-Møller, Susanne Engberg, Esther Steeneveld, Klaus Kirketerp-Møller, Timothy O’Brien, Peter Rossing   +7 more
doaj   +1 more source

Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells

Cells, 2021
Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role in chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown.
Vishnu Amaram Samara, Sadhan Das, Marpadga A. Reddy, Vinay Singh Tanwar, Kenneth Stapleton, Amy Leung, Maryam Abdollahi, Rituparna Ganguly, Linda Lanting, Rama Natarajan   +9 more
doaj   +1 more source

miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Communications Biology, 2021
Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1 ...
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T Fueger, David Chan, Rama Natarajan   +14 more
doaj   +1 more source

Cardiovascular characterisation of a novel mouse model that combines hypertension and diabetes co-morbidities

Scientific Reports, 2023
Epidemiologic data suggest that the prevalence of hypertension in patients with diabetes mellitus is ∼1.5–2.0 times greater than in matched non-diabetic patients.
Arpeeta Sharma, Judy S. Y. Choi, Anna M. D. Watson, Leila Li, Thomas Sonntag, Man K. S. Lee, Andrew J. Murphy, Miles De Blasio, Geoffrey A. Head, Rebecca H. Ritchie, Judy B. de Haan   +10 more
doaj   +1 more source

Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes

Molecular Metabolism, 2021
Background: Insulin has been demonstrated to exert direct and indirect effects on vascular tissues. Its actions in vascular cells are mediated by two major pathways: the insulin receptor substrate 1/2-phosphoinositide-3 kinase/Akt (IRS1/2/PI3K/Akt ...
Jialin Fu, Marc Gregory Yu, Qian Li, Kyoungmin Park, George L. King   +4 more
doaj   +1 more source

The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes

Scientific Reports, 2021
Glucagon-like peptide 1 receptor agonists have shown cardioprotective effects which have been suggested to be mediated through inhibition of oxidative stress.
Suvanjaa Sivalingam, Emil List Larsen, Daniel H. van Raalte, Marcel H. A. Muskiet, Mark M. Smits, Lennart Tonneijck, Jaap A. Joles, Bernt Johan von Scholten, Emilie Hein Zobel, Frederik Persson, Trine Henriksen, Lars Jorge Diaz, Tine W. Hansen, Henrik Enghusen Poulsen, Peter Rossing   +14 more
doaj   +1 more source

The interaction between diabetes, body mass index, hepatic steatosis, and risk of liver resection: insulin dependent diabetes is the greatest risk for major complications [PDF]

, 2014
Background. This study aimed to assess the relationship between diabetes, obesity, and hepatic steatosis in patients undergoing liver resection and to determine if these factors are independent predictors of major complications.
Aroori, S, Bowles, MJ, Lordan, JT, Shahtahmassebi, G, Stell, DA, Wiggans, MG   +5 more
core   +7 more sources

Impact of time‐restricted feeding on kidney injury in male rats with experimental metabolic syndrome

Experimental Physiology, 2023
Disruptions to circadian rhythm may be implicated in the pathogenesis of metabolic syndrome (Met‐S). For example, eating during an extended period of the day may negatively impact the circadian rhythms governing metabolic control, contributing, therefore,
Rajendran Harishkumar, Eva M. Baranda‐Alonso, William P. Martin, Neil G. Docherty   +3 more
doaj   +1 more source

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease

Frontiers in Endocrinology, 2022
BackgroundRoux-en-Y gastric bypass surgery (RYGB) improves biochemical and histological parameters of diabetic kidney disease (DKD). Targeted adjunct medical therapy may enhance renoprotection following RYGB.MethodsThe effects of RYGB and RYGB plus ...
William P. Martin, Yeong H. D. Chuah, Mahmoud Abdelaal, Anders Pedersen, Daniel Malmodin, Sanna Abrahamsson, Michaela Hutter, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Carel W. le Roux, Neil G. Docherty   +12 more
doaj   +1 more source