Results 71 to 80 of about 616,481 (209)
Abstract INTRODUCTION Relationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood. METHODS We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity.
Charles C. Windon +22 more
wiley +1 more source
Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar +8 more
wiley +1 more source
Aim. Assessment of vascular stiffness and endothelial function in patients with type 1 diabetes at different stages of diabetic nephropathy and without it. Materials and methods.
Evgenia Pavlovna Kosobyan +4 more
doaj +1 more source
Diabetic complications and their implications on health care in Asia. [PDF]
Diabetes mellitus is a growing health problem in the Asia-Pacific region. The acute and chronic complications of diabetes mellitus are major causes of hospital admissions, blindness, renal failure, amputations, stroke, and coronary heart disease in this ...
Lam, KS, Leung, GM
core
Abstract Background and objectives Pregnancy‐related reversible cerebral vasoconstriction syndrome (RCVS) has higher rates of intracerebral complications and mortality compared to non‐pregnant RCVS. Case reports suggest preeclampsia‐eclampsia as an important risk factor; however, data are limited regarding this association.
Srinath Ramaswamy +7 more
wiley +1 more source
Omentin-1 and diabetic retinopathy in type 2 diabetic patients [PDF]
Background: Diabetic retinopathy (DR) is one of the most common and serious micro vascular complication affecting type 2 diabetic patients.The literature on adipokines as a possible mechanism in the pathogenesis of DR is contradictory.We are in need for ...
Elgouhary, Sameh Mohamed +2 more
core +2 more sources
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Caso para diagnóstico? Case for diagnosis?
Os autores relatam caso clínico de paciente do sexo masculino, diabético do tipo II insulinodependente, que apresentava lesões eritêmato-acastanhadas no abdômen e nas coxas, com ligeira atrofia assintomática.
Lorivaldo Minelli +2 more
doaj +1 more source
Abstract INTRODUCTION Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers. METHODS The study involved 251 Wake Forest Multi‐Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, magnetic resonance imaging, amyloid positron emission ...
Samuel N. Lockhart +22 more
wiley +1 more source
The Possible Role of Tumor Necrosis Factor-α in Diabetic Polyneuropathy [PDF]
In this review, the authors provide evidences that imply the role of tumor necrosis factor-α (TNF-α) in the pathogenesis of diabetic complications, especially diabetic polyneuropathy.
Satoh, Jo +2 more
core +3 more sources

