Results 161 to 170 of about 142,256 (292)

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

The Prevalence and Death Risk Factors of Nonthyroidal Illness Syndrome in Patients During Hospitalization With Diabetic Foot Ulcers

International Journal of Endocrinology
Hong-ping Gong, Yan Ren, Zhen-yi Li, Pan-pan Zha, Raju Bista, Yan Li, Da-wei Chen, Yun Gao, Li-hong Chen, Hui Huang, Xing-wu Ran, Chun Wang   +11 more
doaj   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Comment on: “GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”

Advanced Science, EarlyView.
ABSTRACT The recent study by Wang et al. introduces GLM7, a novel composite index integrating routine health indicators to enhance the diagnosis and prediction of multimorbidity. The study provides compelling evidence for the utility of cost‐effective biomarkers in large‐scale health screening.
Yiquan Wang, Tin‐Yeh Huang
wiley   +1 more source

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Poria cocos is known as an edible mushroom for food and medicine. Poria cocos and its terpenes and terpenoids serve as novel remedies to treat diabetes and its ulcers. Its mode of actions includes reduction of insulin resistance, starch digestion and inflammation as well as promotion of blood vessel formation. ABSTRACT Poria cocos is a medicinal fungus
Yi‐San Lee, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +3 more
wiley   +1 more source

Combining thermography and artificial intelligence in comparison with a diabetic foot nurse for diabetic foot ulcer detection: A diagnostic accuracy study. [PDF]

Digit Health
Shara K, Alghali M, Abu-Ashour W, Almnaizel AT, Sunbul T, Baatiah N, Attal K, Al Attallah I, Sawad B, Alwashmi M.   +9 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Understanding diabetic foot

International Journal of Diabetes in Developing Countries, 2010
openaire   +3 more sources

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source