Results 21 to 30 of about 80,312 (314)

Role of M1 macrophages in diabetic foot ulcers and related immune regulatory mechanisms

Frontiers in Pharmacology, 2023
Objectives: Diabetes foot ulcers (DFUs) are characterized by immune infiltration of M1 macrophages observed in foot skin, in which immune-associated genes (IRGs) play a prominent role.
Yao Li, Yao Li, Xiaoyan Li, Xiaoyan Li, Shuai Ju, Shuai Ju, Wenqiang Li, Wenqiang Li, Siyuan Zhou, Siyuan Zhou, Siyuan Zhou, Guili Wang, Guili Wang, Guili Wang, Yunmin Cai, Yunmin Cai, Zhihui Dong, Zhihui Dong, Zhihui Dong   +18 more
doaj   +1 more source

Bacterial Diversity and Antibiotic Resistance in Patients with Diabetic Foot Osteomyelitis

Antibiotics, 2023
This study analysed the bacterial diversity, antibiotic susceptibility, and resistance in patients with complications of diabetic foot osteomyelitis (DFO).
Francisco Javier Álvaro-Afonso, Yolanda García-Álvarez, Aroa Tardáguila-García, Marta García-Madrid, Mateo López-Moral, José Luis Lázaro-Martínez   +5 more
doaj   +1 more source

The Diabetic Foot

Current Pharmaceutical Design, 2018

Glaudemans, Andor W. J. M., Kwee, Thomas C., Slart, Riemer H. J. A.   +2 more
openaire   +3 more sources

Diagnostic Accuracy of Oxygen Desaturation Index for Sleep-Disordered Breathing in Patients With Diabetes

Frontiers in Endocrinology, 2021
BackgroundPolysomnography (PSG) is the gold standard for diagnosis of sleep-disordered breathing (SDB). But it is impractical to perform PSG in all patients with diabetes.
Lihong Chen, Weiwei Tang, Chun Wang, Dawei Chen, Yun Gao, Wanxia Ma, Panpan Zha, Fei Lei, Xiangdong Tang, Xingwu Ran   +9 more
doaj   +1 more source

Association between vitamin D status and diabetic foot in patients with type 2 diabetes mellitus

Journal of Diabetes Investigation, 2022
Aims/Introduction To assess the association between vitamin D and diabetic foot (DF) in patients with type 2 diabetes mellitus (T2DM), in order to summarize clinical evidence in the prevention and treatment of DF.
Weiwei Tang, Lihong Chen, Wanxia Ma, Dawei Chen, Chun Wang, Yun Gao, Xingwu Ran   +6 more
doaj   +1 more source

Comparison of Heart Rate Variability in People With Diabetes-Related Neuropathic Foot to Their Counterparts Without a Foot Ulcer History: A Propensity Score Matching Study

Journal of Diabetes Research
Conclusion: Among people with neuropathic diabetic foot only, cardiac autonomic function was still more severely impaired in individuals with DFU than in their counterparts without DFU.
Murong Wu, Shuang Lin, Yan Liu, Dawei Chen, Xingwu Ran, Chun Wang, Lihong Chen, Sen He, Donge Yan, Mingxin Bai, Yingying Dong, Wen Wang, Zhiyi Lei, Yun Gao   +13 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The correlation between serum vitamin D status and the occurrence of diabetic foot ulcers: a comprehensive systematic review and meta‐analysis

Scientific Reports
The association between vitamin D concentrations and the occurrence of diabetic foot ulcers (DFUs) remains a topic of ongoing debate. In order to provide a comprehensive and updated review, we conducted this meta‐analysis to further investigate the ...
Weiwei Tang, Dawei Chen, Lihong Chen, Guanjian Liu, Shiyi Sun, Chun Wang, Yun Gao, Xingwu Ran   +7 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source