Results 31 to 40 of about 64,717 (264)

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Role of M1 macrophages in diabetic foot ulcers and related immune regulatory mechanisms

Frontiers in Pharmacology, 2023
Objectives: Diabetes foot ulcers (DFUs) are characterized by immune infiltration of M1 macrophages observed in foot skin, in which immune-associated genes (IRGs) play a prominent role.
Yao Li, Yao Li, Xiaoyan Li, Xiaoyan Li, Shuai Ju, Shuai Ju, Wenqiang Li, Wenqiang Li, Siyuan Zhou, Siyuan Zhou, Siyuan Zhou, Guili Wang, Guili Wang, Guili Wang, Yunmin Cai, Yunmin Cai, Zhihui Dong, Zhihui Dong, Zhihui Dong   +18 more
doaj   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Prevalence and Severity of Coronary Artery Calcification Assessed by Low‐Dose Computed Tomography in Individuals With Type 2 Diabetes With and Without Diabetic Foot: A Cross‐Sectional Study

Journal of Diabetes
Background To investigate whether diabetic foot (DF) is associated with a higher prevalence and severity of coronary artery calcification (CAC) in patients with type 2 diabetes (T2DM) using low‐dose computed tomography (LDCT).
Feiyan Shi, Yun Gao, Mingxin Bai, Ruixue Feng, Chunjie Ma, Dawei Chen, Chun Wang, Lihong Chen, Sen He, Donge Yan, Chunchao Xia, Xingwu Ran   +11 more
doaj   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Bacterial Diversity and Antibiotic Resistance in Patients with Diabetic Foot Osteomyelitis

Antibiotics, 2023
This study analysed the bacterial diversity, antibiotic susceptibility, and resistance in patients with complications of diabetic foot osteomyelitis (DFO).
Francisco Javier Álvaro-Afonso, Yolanda García-Álvarez, Aroa Tardáguila-García, Marta García-Madrid, Mateo López-Moral, José Luis Lázaro-Martínez   +5 more
doaj   +1 more source

Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns

Arthritis Care &Research, Accepted Article.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen, Yasuo Nagafuchi, Kristina Lend, Seyam Alemyar, Herman Kasper Glas, Gerdur Gröndal, Bjorn Gudbjornsson, Espen A. Haavardsholm, Kim Hørslev Petersen, Jon Lampa, Merete Lund Hetland, Dan Nordström, Mike Nurmohamed, Mikkel Østergaard, Anna Rudin, Marte Schrumpf Heiberg, Tuulikki Sokka‐Isler, Till Uhlig, Josien Veris‐van Dieren, Ronald van Vollenhoven, Tom Huizinga, Marcel JT Reinders, Sytske Anne Bergstra, Erik van den Akker, Rachel Knevel   +24 more
wiley   +1 more source

Limb Preservation for Multiple Ray Osteomyelitis in Diabetic Forefoot Charcot: A Case Report

Case Reports in Orthopedics
This case report describes a very rare presentation of multifocal diabetic foot osteomyelitis (DFO) involving multiple rays and associated with forefoot Charcot neuroarthropathy.
Kaissar Yammine, Marc Ghattas
doaj   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High Body Mass Index

Arthritis Care &Research, EarlyView.
Objective High body mass index (BMI ≥ 27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

Association between vitamin D status and diabetic foot in patients with type 2 diabetes mellitus

Journal of Diabetes Investigation, 2022
Aims/Introduction To assess the association between vitamin D and diabetic foot (DF) in patients with type 2 diabetes mellitus (T2DM), in order to summarize clinical evidence in the prevention and treatment of DF.
Weiwei Tang, Lihong Chen, Wanxia Ma, Dawei Chen, Chun Wang, Yun Gao, Xingwu Ran   +6 more
doaj   +1 more source