Results 21 to 30 of about 634,611 (282)

The association of chronic, enhanced immunosuppression with outcomes of diabetic foot infections

Endocrinology, Diabetes & Metabolism, 2022
We investigated if a chronic, enhanced immunosuppressed condition, beyond the immunodeficiency related to diabetes, is associated with clinical failures after combined surgical and medical treatment for diabetic foot infection (DFI).
Ilker Uçkay, Madlaina Schöni, Martin C. Berli, Fabian Niggli, Emil Noschajew, Benjamin A. Lipsky, Felix W. A. Waibel   +6 more
doaj   +1 more source

The Charcot Foot in Diabetes [PDF]

Diabetes Care, 2011
The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners. Now considered an inflammatory syndrome, the diabetic Charcot foot is characterized by varying degrees of bone and ...
Rogers, Lee C., Frykberg, Robert G., Armstrong, David G., Boulton, Andrew J M, Edmonds, Michael, Ha Van, Georges, Hartemann, Agnes, Game, Frances, Jeffcoate, William, Jirkovska, Alexandra, Jude, Edward, Morbach, Stephan, Morrison, William B., Pinzur, Michael, Pitocco, Dario, Sanders, Lee, Wukich, Dane K., Uccioli, Luigi, Rogers, LC, Frykberg, RG, Armstrong, DG, Van, GH, Morrison, WB, Wukich, DK   +23 more
openaire   +5 more sources

Successful nonsurgical therapy of a diabetic foot osteomyelitis in a patient with peripheral artery disease with almost complete radiological restoration

BMC Research Notes, 2018
Background Diabetic foot ulcer (DFU) is a common complication in patients with diabetes mellitus (DM) and can consequently lead to soft tissue infection and osteomyelitis.
C. V. Loupa, E. Meimeti, E. Voyatzoglou, A. Donou, E. Koutsantoniou, S. Lafoyanni   +5 more
doaj   +1 more source

Effects of novel diabetic therapeutic footwear on preventing ulcer recurrence in patients with a history of diabetic foot ulceration: study protocol for an open-label, randomized, controlled trial

Trials, 2021
Background Recurrence after the healing of a foot ulcer is very common among patients with diabetes mellitus. Novel diabetic therapeutic footwear consisted of merino wool, vibration chip, and orthopedic insoles is designed to influence multifaceted ...
Yun Gao, Chun Wang, Dawei Chen, Hui Huang, Lihong Chen, Guanjian Liu, Shuang Lin, Min Liu, Xiaorong Wen, Jae-Hoon Cho, Yong Chen, Yingzhu Li, Xingwu Ran   +12 more
doaj   +1 more source

Surgical Management of Diabetic Foot Ulcers: A Tanzanian University Teaching Hospital Experience. [PDF]

, 2011
\ud \ud Diabetic foot ulcers (DFUs) pose a therapeutic challenge to surgeons, especially in developing countries where health care resources are limited and the vast majority of patients present to health facilities late with advanced foot ulcers.
Kabangila Rodrick, Gilyoma, J.M., Mbelenge, N., Gilyoma, Japhet M, Rodrick Kabangila, Dass, R.M., Phillipo L Chalya, Chalya Phillipo L, Joseph B Mabula, Mchembe Mabula D, Jaka Hyasinta, Jaka, H., Nkinda Mbelenge, Mchembe, M.D., Jaka, Hyasinta, Mabula Joseph B, Kataraihya, Johannes B, Mbelenge, Nkinda, Gilyoma Japhet M, Mabula D Mchembe, Johannes B Kataraihya, Kataraihya, J.B., Dass Ramesh M, Chalya, Phillipo L, Chalya, P.L., McHembe, Mabula D, Kabangila, Rodrick, Mabula, J.B., Hyasinta Jaka, Dass, Ramesh M, Mbelenge Nkinda, Kataraihya Johannes B, Kabangila, R., Ramesh M Dass, Japhet M Gilyoma, Mabula, Joseph B   +35 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Comparison of Heart Rate Variability in People With Diabetes-Related Neuropathic Foot to Their Counterparts Without a Foot Ulcer History: A Propensity Score Matching Study

Journal of Diabetes Research
Conclusion: Among people with neuropathic diabetic foot only, cardiac autonomic function was still more severely impaired in individuals with DFU than in their counterparts without DFU.
Murong Wu, Shuang Lin, Yan Liu, Dawei Chen, Xingwu Ran, Chun Wang, Lihong Chen, Sen He, Donge Yan, Mingxin Bai, Yingying Dong, Wen Wang, Zhiyi Lei, Yun Gao   +13 more
doaj   +1 more source

Role of M1 macrophages in diabetic foot ulcers and related immune regulatory mechanisms

Frontiers in Pharmacology, 2023
Objectives: Diabetes foot ulcers (DFUs) are characterized by immune infiltration of M1 macrophages observed in foot skin, in which immune-associated genes (IRGs) play a prominent role.
Yao Li, Yao Li, Xiaoyan Li, Xiaoyan Li, Shuai Ju, Shuai Ju, Wenqiang Li, Wenqiang Li, Siyuan Zhou, Siyuan Zhou, Siyuan Zhou, Guili Wang, Guili Wang, Guili Wang, Yunmin Cai, Yunmin Cai, Zhihui Dong, Zhihui Dong, Zhihui Dong   +18 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Bacterial Diversity and Antibiotic Resistance in Patients with Diabetic Foot Osteomyelitis

Antibiotics, 2023
This study analysed the bacterial diversity, antibiotic susceptibility, and resistance in patients with complications of diabetic foot osteomyelitis (DFO).
Francisco Javier Álvaro-Afonso, Yolanda García-Álvarez, Aroa Tardáguila-García, Marta García-Madrid, Mateo López-Moral, José Luis Lázaro-Martínez   +5 more
doaj   +1 more source