Results 51 to 60 of about 64,717 (264)

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Adipose Tissue Grafting: A New Paradigm in Diabetic Foot Treatment

Diabetology
Background: Adipose tissue grafting is a regenerative medicine approach based on the use of autologous adipose tissue showing significant potential for the treatment of diabetic foot lesions.
Roberto Da Ros, Roberta Assaloni, Andrea Michelli, Barbara Brunato, Enrica Barro, Marta Nardi, Giovanni Papa, Cesare Miranda   +7 more
doaj   +1 more source

Diabetic Foot Australia guideline on footwear for people with diabetes

Journal of Foot and Ankle Research, 2018
Background The aim of this paper was to create an updated Australian guideline on footwear for people with diabetes. Methods We reviewed new footwear publications, (inter)national guidelines, and consensus expert opinion alongside the 2013 Australian ...
Jaap J. van Netten, Peter A. Lazzarini, David G. Armstrong, Sicco A. Bus, Robert Fitridge, Keith Harding, Ewan Kinnear, Matthew Malone, Hylton B. Menz, Byron M. Perrin, Klaas Postema, Jenny Prentice, Karl-Heinz Schott, Paul R. Wraight   +13 more
doaj   +1 more source

Conformal Coating and Transfer of 2D Nanomaterials via Dynamic Interface Engineering

Advanced Materials Interfaces, EarlyView.
This review discusses conformal coating and transfer of two‐dimensional (2D) nanomaterials with a focus on dynamic interface engineering. By actively regulating nanosheet transport and interfacial contact during film formation, recent dynamic coating strategies overcome the limitations of conventional passive approaches and enable geometry‐adaptive ...
Seungyeon Kim, Euihoon Jeong, Seoung‐Ki Lee, Sukang Bae, Tae‐Wook Kim   +4 more
wiley   +1 more source

Antibiotic and Surgical Treatment of Diabetic Foot Osteomyelitis: The Histopathological Evidence

Antibiotics
Background: Osteomyelitis is one of the most frequent infections of the diabetic foot, accounting for 20–70% of foot infections. The treatment of osteomyelitis continues to be debated, and the possibility of performing conservative surgery associated ...
Roberto Da Ros, Roberta Assaloni, Andrea Michelli, Barbara Brunato, Cesare Miranda   +4 more
doaj   +1 more source

Study of toe deformities in diabetic foot through Amit Jain’s extended ‘SCC’ classification

Medicine Science, 2020
A study was conducted to analyze the visible named toe deformities that occur in foot of patients with diabetes through the new Amit Jain’s extended ‘SCC’ classification. A total of 27 patients were included who fulfilled the criteria.
Amit Kumar C Jain, Apoorva HC
doaj   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Bone Substitute in Diabetic Foot Osteomyelitis Treatment

Diabetology
Background: Diabetic foot osteomyelitis (DFO) constitutes a severe and prevalent complication of diabetes mellitus (DM). Individuals afflicted with DM exhibit an elevated risk for DFO development, attributable to a confluence of factors, including ...
Roberto Da Ros, Roberta Assaloni, Andrea Michelli, Barbara Brunato, Enrica Barro, Cesare Miranda   +5 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

HUC-MSCs combined with platelet lysate treat diabetic chronic cutaneous ulcers in Bama miniature pig

Regenerative Therapy
Human umbilical cord mesenchymal stem cells (HUC-MSCs) and platelet lysate (PL) shows potential of wound healing. However, MSCs in combination with PL for wound healing is still lacking.
Yunyi Gao, Lihong Chen, Yan Li, Shiyi Sun, XingWu Ran   +4 more
doaj   +1 more source