Results 71 to 80 of about 78,086 (312)
, 2000 Diabetes mellitus is the number one cause of limb loss in North America, and is associated with growing, unacceptable rates of morbidity, mortality and economic loss.
Gordon Dow +1 more
core +1 more source
NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks
Advanced Science, EarlyView.This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang +10 more
wiley +1 more source
Diabetic foot ulceration with osteomyelitis: the importance of early detection
, 2008 This case study explores the management of a chronic diabetic foot ulcer complicated by severe soft tissue infection (cellulitis) and bony infection (osteomyelitis) in a patient with type 2 ...
Tranter, Jennifer, McIntosh, Caroline
core
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
International Journal of Endocrinology, 2017 Objective. To evaluate the concordance between oscillometric ABI and standard Doppler ABI in diabetic Chinese patients with or without diabetic foot. Methods. 230 consecutive diabetic patients (n=459 limbs) were included.
Jing Ma +5 more
doaj +1 more source
, 2020 Evidence-based guidelines, such as those provided by the International WorkingGroup on the Diabetic Foot (IWGDF), are essential to support high-quality clinicalmanagement and outcomes of diabetic foot ulceration.
Lazzarini, Peter A., +3 more
core
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
IMC Journal of Medical Science, 2010 A case of amputation of the fourth toe is described in a diabetic patient. The patient had overlapping of third and fourth toes since her childhood and later she developed soft lipomas over the fourth toe and lateral aspect of the dorsum of the foot. The
Faria Afsana +2 more
doaj
Burden of Infected Diabetic Foot Ulcers on Hospital Admissions and Costs in a Third-Level Center
DiabetologyDiabetic foot is a common complication of diabetes that affects quality and prognosis of life for patients and often requires hospitalization. Infection, alone or in association with ischemia, is the main cause of hospital admission and impacts prognosis.
Roberto Da Ros +6 more
doaj +1 more source
Recurrent Admissions for Diabetic Foot Complications [PDF]
, 2013 Diabetic foot complications are a significant source of morbidity and mortality. Patients who undergo recurrent admissions for the same diabetic foot problems represent a difficult subgroup to treat.
Ang CL, Lim YJ
core +1 more source