Results 91 to 100 of about 44,427 (283)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Impaired quality of life and diabetic foot disease in Saudi patients with type 2 diabetes: A cross-sectional analysis

SAGE Open Medicine, 2019
Objectives: This study aimed to assess the overall health-related quality of life in type 2 diabetes mellitus patients with diabetic foot disease compared to diabetic patients without diabetic foot and to identify the clinical utility of this assessment.
Sana A AlSadrah
doaj   +1 more source

Evaluation of the Surgical and Pharmacological Treatment of Diabetic Foot Infection: A Retrospective Study [PDF]

, 2017
BACKGROUND: Diabetic foot infection is a major cause of patient disabilities and lowers limb amputations, with high treatment costs and hospitalisation requirements.
Aliakbar, Adil Hassan, Alsaadi, Malath Azeez, Barrak, Abbas Abd Zaid   +2 more
core   +4 more sources

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Next Generation Footwear for Diabetic Neuropathy: A Narrative Review on Biomechanical Innovations and Smart Technologies for Ulcer Prevention [PDF]

Journal of Clinical and Diagnostic Research
Diabetic Neuropathy (DN) significantly alters foot biomechanics, leading to abnormal pressure distribution, impaired gait patterns, and a heightened risk of foot ulcers, which often precede lower-limb amputations. Traditional diabetic footwear focuses on
Chhavi Arora Sehgal, Ruchi Basista, Sanghamitra Jena, Majumi M Noohu, Nitesh Malhotra   +4 more
doaj   +1 more source

Use of m-Health Technology for Preventive Interventions to Tackle Cardiometabolic Conditions and Other Non-Communicable Diseases in Latin America- Challenges and Opportunities [PDF]

, 2016
In Latin America, cardiovascular disease (CVD) mortality rates will increase by an estimated 145% from 1990 to 2020. Several challenges related to social strains, inadequate public health infrastructure, and underfinanced healthcare systems make ...
Beratarrechea, Andrea Gabriela, Diez Canseco, Francisco, Irazola, Vilma, Miranda, Jaime, Ramirez Zea, Manuel, Rubinstein, Adolfo Luis   +5 more
core   +1 more source

Physicochemical and Mechanical Characterization of Commercial Collagen‐Based Wound Dressings

Advanced NanoBiomed Research, EarlyView.
Commercial collagen‐based wound dressings are systematically compared to reveal how porous architecture governs hydration‐driven swelling and mechanical adaptation. Distinct structure–function relationships are identified, showing that wet‐state elasticity and conformability emerge from material composition and processing rather than manufacturer ...
Davide V. Verdolino, David M. Warde, Helen A. Thomason, Kimberly A. Mace, Sarah H. Cartmell   +4 more
wiley   +1 more source

Foot complications among diabetics attending a district hospital in Kenya: Predisposing factors and possible intervention

The Annals of African Surgery, 2008
OBJECTIVES: To relate skin health, footwear practices and foot care education with occurrence of foot complications among diabetics attending a district hospital in Kenya.
M.M. Obimbo, P.K. Bundi, F. Collis
doaj