Results 61 to 70 of about 13,469 (305)

Comparison of Blood Pressure and Blood Glucose Level Among Elderly with Non-communicable Disease [PDF]

, 2019
Due to increasing age, elderly are prone to non-communicable diseases (NCD), such as hypertension (HT) and diabetes mellitus (DM). Easy physical condition monitoring of people with HT and/or DM is by measuring their blood pressure (BP) and/or blood ...
Artsanthia, J. (Jintana), Sari, N. P. (Ni)   +1 more
core  

Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis. [PDF]

, 2014
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood.
Chan, LYY, Lai, KN, Leung, JCK, Li, RX, Lian, Q, Lin, M, Tang, SCW, Tse, HF, Wong, DWL, Wu, HJ, Yiu, WH, Zhang, Y   +11 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with changes in laboratory markers of renal damage among patients with type 2 diabetes mellitus [PDF]

Archives of Endocrinology and Metabolism
Objective: To investigate the association between the rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus.
Luciane Moretto, Eliandra Girardi, Anna Carolina Meireles Vieira, Letícia de Almeida Brondani, Natália Emerim Lemos, Luís Henrique Canani, Marilu Fiegenbaum, Cristine Dieter, Daisy Crispim   +8 more
doaj   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Advanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He, Jing Li, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yingming Xu, Shuang Ge, Yexing Zhang, Yizhi Wang, Xinrui Chen, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Peizhen Hu, Qiang Huang, Zihan Wang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Jiurun Chen, Zhen Song, Chao He, Zhe Wang, Yonghong He   +28 more
wiley   +1 more source

A machine learning model for predicting worsening renal function using one‐year time series data in patients with type 2 diabetes

Journal of Diabetes Investigation
Background and Aims To prevent end‐stage renal disease caused by diabetic kidney disease, we created a predictive model for high‐risk patients using machine learning.
Mari Watanabe, Shu Meguro, Kaiken Kimura, Michiaki Furukoshi, Tsuyoshi Masuda, Makoto Enomoto, Hiroshi Itoh   +6 more
doaj   +1 more source

Doença Renal na Região Autónoma da Madeira: Experiência de Vinte e Sete Anos de Biópsias de Rim Nativo [PDF]

, 2014
Introduction: Renal biopsy plays an essential role either in the diagnosis or in the prognosis of patients with renal disease. In order to assess its epidemiology and evolution in Madeira Islands, we analysed twenty-seven years of native kidney biopsies.
Alves Teixeira, Araújo, J, Brinca, A, Carvalho, F, Durães, JM, Galvão, MJ, Gonçalves, AM, Resende, L, Rodrigues, F, Rosa, N, Silva, G, Viana, H, Vieira, P   +12 more
core   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Novel thinking of renal pathology on the diagnosis and prognosis of diabetic nephropathy

Linchuang shenzangbing zazhi, 2021
Diabetes mellitus（DM）has been a great challenge to human health. is As one of the most important complications, diabetic nephropathy（DN）is a major cause of end-stage renal disease（ESRD）.
Zhou Ting, Wang Nian-song, Fan Ying
doaj  

Idiopathic nodular glomerulosclerosis and differential diagnosis

Brazilian Journal of Nephrology, 2020
Introduction: Idiopathic nodular glomerulosclerosis (ING) is a condition that has a vasculopathic glomerular histological pattern. Case presentation: The authors present the case of a 44-year-old Hispanic smoker female with hypertension and peripheral ...
Sergio Raúl Alvizures Solares, Héctor Raúl Ibarra-Sifuentes, María Guadalupe Ramírez Ramírez, Giovanna Yazmin Arteaga Muller, Jesús Cruz Valdez   +4 more
doaj   +2 more sources