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Pyroptosis in diabetes and diabetic nephropathy
Clinica Chimica Acta, 2022Pyroptosis is identified as a pro-inflammatory programmed cell death, mediated by gasdermins (GSDMs) family of proteins accompanied by pro-inflammatory signals release. As essential players in innate immunity, inflammasomes are intracellular protein complexes which cleave gasdermin D (GSDMD), forming structurally stable pores in the cell membrane ...
Zhaohui, Cao +6 more
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2012
The most common cause of end stage renal disease (ESRD) requiring dialysis is diabetes. Both environmental and genetic factors have been postulated as the risk factors of Diabetic Nephropathy (DN). Hyperglycemia-induced metabolic and hemodynamic pathways are recognized to be mediators of kidney injury. Multiple biochemical pathways have been postulated
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The most common cause of end stage renal disease (ESRD) requiring dialysis is diabetes. Both environmental and genetic factors have been postulated as the risk factors of Diabetic Nephropathy (DN). Hyperglycemia-induced metabolic and hemodynamic pathways are recognized to be mediators of kidney injury. Multiple biochemical pathways have been postulated
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Pediatric Clinics of North America, 1984
It is estimated that about 50 per cent of all patients with Type I diabetes mellitus develop uremia during the course of their disease. Glomerular microvasculopathy is the most serious and predictable threat to longevity. Following a discussion of this disorder, the author outlines a plan for overall management of each phase of kidney disease so that ...
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It is estimated that about 50 per cent of all patients with Type I diabetes mellitus develop uremia during the course of their disease. Glomerular microvasculopathy is the most serious and predictable threat to longevity. Following a discussion of this disorder, the author outlines a plan for overall management of each phase of kidney disease so that ...
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Proteomics and Diabetic Nephropathy
Seminars in Nephrology, 2005Diabetes mellitus is acknowledged to be a group of metabolic diseases and heterogeneous in natural history, pathogenesis, response to treatment, and disease progression and remission. Diabetic nephropathy (DN) accounts for approximately 40% of all newly diagnosed cases of end-stage renal disease.
Michael L, Merchant, Jon B, Klein
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Diabetic Nephropathy and Pregnancy
Clinical Obstetrics and Gynecology, 1991Knowledge of the pathogenic mechanisms of diabetic nephropathy (by which hyperglycemia, hyperfiltration, and hypertension cause the gradual development of microproteinuria, mesangial expansion, and eventual glomerular closure) provides the basis for effective treatment.
C A, Combs, J L, Kitzmiller
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Irish Journal of Medical Science, 1979
Since the original recognition by Kimmelstiel and Wilson in 1936 of a characteristic nodular lesion in diabetic renal glomeruli, no simple relationship has been demonstrated between the structural and functional defects now known to exist in diabetic renal disease.
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Since the original recognition by Kimmelstiel and Wilson in 1936 of a characteristic nodular lesion in diabetic renal glomeruli, no simple relationship has been demonstrated between the structural and functional defects now known to exist in diabetic renal disease.
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Glycation in diabetic nephropathy
Amino Acids, 2010The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D.
Forbes, Josephine M., Cooper, Mark E.
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Archives of Family Medicine, 1996
Diabetic nephropathy is an important microvascular complication of both insulin-dependent and non-insulin-dependent diabetes mellitus. It is the leading cause of end-stage renal disease. The natural course, pathogenesis, clinical evaluation, and treatment of diabetic nephropathy were reviewed, with special emphasis on recent important studies of ...
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Diabetic nephropathy is an important microvascular complication of both insulin-dependent and non-insulin-dependent diabetes mellitus. It is the leading cause of end-stage renal disease. The natural course, pathogenesis, clinical evaluation, and treatment of diabetic nephropathy were reviewed, with special emphasis on recent important studies of ...
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Diabetic Nephropathy in the Elderly
Clinics in Geriatric Medicine, 2009Although diabetes is clearly linked to macro- and microvasculopathy in multiple organs resulting in cardiovascular and cerebrovascular catastrophic diseases, blindness, and limb amputations, it is the relentless progression of diabetic nephropathy toward becoming the major cause of end-stage renal disease (ESRD) that now challenges budgets and ...
Anthony J, Joseph, Eli A, Friedman
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Diabetes Research and Clinical Practice, 1994
According to a nation-wide survey of dialysis patients in Japan the number of diabetic patients with end-stage renal failure introduced to dialysis therapy has been increasing year by year, exceeding 6000 cases (28% of total cases) in 1991. A six-fold increase in numbers and a three-fold increase in percentages (DM/total) were observed in the past ten ...
Y, Shigeta, R, Kikkawa
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According to a nation-wide survey of dialysis patients in Japan the number of diabetic patients with end-stage renal failure introduced to dialysis therapy has been increasing year by year, exceeding 6000 cases (28% of total cases) in 1991. A six-fold increase in numbers and a three-fold increase in percentages (DM/total) were observed in the past ten ...
Y, Shigeta, R, Kikkawa
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