Results 81 to 90 of about 878,879 (388)

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes mellitus

Journal of Diabetes Investigation, 2021
Aims/Introduction Non‐alcoholic fatty liver disease and type 2 diabetes mellitus are closely related, and often occur simultaneously in patients. Type 2 diabetes increases the risk of diabetic peripheral neuropathy, resulting in intolerable pain and ...
Jinya Huang, Rumei Li, Naijia Liu, Na Yi, Hangping Zheng, Qi Zhang, Lianying Zhou, Linuo Zhou, Renming Hu, Bin Lu   +9 more
doaj   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Neuropathy - gait changes in the diabetic foot [PDF]

, 2008
Motor neuropathy in patients with diabetes can lead to weakness in the muscles of the foot and lower leg, which in turn can lead to characteristic changes to the structure of the foot, such as an altered arch profile.
McIntosh, Caroline, Newton, Veronica
core  

Teleneurology clinics for polyneuropathy: a pilot study. [PDF]

, 2020
INTRODUCTION:Polyneuropathy (PN) is a common condition with significant morbidity. We developed tele-polyneuropathy (tele-PN) clinics to improve access to neurology and increase guideline-concordant PN care.
Cheng, Eric M, Hanssen, Andrea, Inkelas, Moira, Jamal, Nasheed I, Ong, Michael K, Saliba, Debra, Torres, Jorge A, Wilson, Andrew M   +7 more
core  

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Early detection of diabetic neuropathy based on health belief model: a scoping review

Frontiers in Endocrinology
IntroductionUncontrolled blood sugar levels may result in complications, namely diabetic neuropathy. Diabetic neuropathy is a nerve disorder that causes symptoms of numbness, foot deformity, dry skin, and thickening of the feet.
Okti Sri Purwanti, Okti Sri Purwanti, Nursalam Nursalam, Moses Glorino Rumambo Pandin   +3 more
doaj   +1 more source

High resolution ultrasonography of the tibial nerve in diabetic peripheral neuropathy

Journal of Ultrasonography, 2017
Aim of the study: High-resolution ultrasonography of the tibial nerve is a fast and non invasive tool for diagnosis of diabetic peripheral neuropathy. Our study was aimed at finding out the correlation of the cross sectional area and maximum thickness ...
Kunwarpal Singh, Kamlesh Gupta, Sukhdeep Kaur   +2 more
doaj   +1 more source

Topical treatment of peripheral neuropathic pain: applying the evidence [PDF]

, 2017
Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events.
Cruccu, Giorgio, Sommer, Claudia
core   +1 more source

Effect of static magnetic field therapy on diabetic neuropathy and quality of life: a double-blind, randomized trial [PDF]

, 2023
A. Nazeri, Ali Mohammadpour, Mohammad-Hadi Saeed Modaghegh, Mojtaba Kianmehr   +3 more
openalex   +1 more source