Results 91 to 100 of about 1,254,591 (276)

Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy.

, 2011
Despite its prevalence, clinical and prognostic impact, diabetic autonomic neuropathy, is widely under-diagnosed. The need for training and expertise to perform the cardiovascular tests (usually the task of diabetologists) is one possible reason.
QUADRI R, BAX G, MELGA P, MAULE S, CORTELLI P, BELLAVERE F, DIABETIC NEUROPATHY STUDY GROUP OF THE ITALIAN SOCIETY OF DIABETOLOGY, MORGANTI R, VIVIANI, GIORGIO LUCIANO, ESPOSITO K, SPALLONE V, SCIONTI L   +11 more
core   +3 more sources

Understanding of Statistical Terms Routinely Used in Presentations: A Survey among Residents who participate at a Summer School

Applied Medical Informatics, 2014
Aim: The aim of our study was to investigate the understanding of statistical terms commonly used in lectures presented at summer schools for residents and young specialists.
Cosmina-Ioana BONDOR, Norina Alinta GÂVAN, Ina-Maria KACSO   +2 more
doaj  

Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study

Endocrine Connections, 2019
Objective Vitamin B12 deficiency resulting from metformin use has been demonstrated in multiple studies. In this study, we aimed to evaluate the prevalence of vitamin B12 deficiency in patients with chronic metformin use and the relationship between ...
M. Alvarez, Oswaldo Rincón Sierra, G. Saavedra, S. Moreno   +3 more
semanticscholar   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source

Schwann cell interactions with axons and microvessels in diabetic neuropathy

Nature Reviews Neurology, 2017
The prevalence of diabetes worldwide is at pandemic levels, with the number of patients increasing by 5% annually. The most common complication of diabetes is peripheral neuropathy, which has a prevalence as high as 50% and is characterized by damage to ...
N. Gonçalves, C. Vægter, H. Andersen, L. Østergaard, N. Calcutt, T. Jensen   +5 more
semanticscholar   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Corneal Sensitivity as a Potential Marker of Diabetic Neuropathy

Acta Medica Indonesiana, 2017
Diabetes mellitus (DM) is a complex and chronic metabolic disorder leading to many complications. One of the most common complications of DM is diabetic neuropathy.
Ratna Sitompul
doaj   +2 more sources

Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy

PLoS ONE, 2017
Objectives Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible technique that quantifies small nerve fibres. We have compared the diagnostic capability of CCM against a range of established measures of nerve damage in patients with ...
U. Alam, M. Jeziorska, I. Petropoulos, O. Asghar, H. Fadavi, G. Ponirakis, A. Marshall, M. Tavakoli, A. Boulton, N. Efron, R. Malik   +10 more
semanticscholar   +1 more source

Exposure–Response Analysis of Enfortumab Vedotin Plus Pembrolizumab as First‐Line Therapy for Locally Advanced or Metastatic Urothelial Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Enfortumab vedotin is a nectin‐4‐directed antibody–drug conjugate currently approved in combination with pembrolizumab for the first‐line treatment of locally advanced or metastatic urothelial cancer. Here we describe the exposure–response relationship between enfortumab vedotin exposures and efficacy/safety endpoints in patients who received ≥1 dose ...
Vaishali L. Chudasama, Helen Kastrissios, Hossam Kadry, Daping Zhang, Salaheldin Hamed, Srinivasu Poondru, Souvik Bhattacharya, Russ Wada, Amit Garg, Yen Lin Chia   +9 more
wiley   +1 more source