Results 1 to 10 of about 448,569 (309)

The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy

Biomedicines, 2022
Paclitaxel is a widely used anticancer drug that induces dose-limiting peripheral neuropathy. Mitochondrial dysfunction has been implicated in paclitaxel-induced neuronal damage and in the onset of peripheral neuropathy. We have previously shown that the
Hye-Ji Jang, Young-Yeon Kim, Kang-Min Lee, Jung-Eun Shin, Jeanho Yun   +4 more
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Falls and fractures associated with type 2 diabetic polyneuropathy: A cross‐sectional nationwide questionnaire study

Journal of Diabetes Investigation, 2021
Aims/Introduction To examine the prevalence of falls and fractures, and the association with symptoms of diabetic polyneuropathy (DPN) in patients with recently diagnosed type 2 diabetes.
Karolina Snopek Khan, Diana Hedevang Christensen, Sia Kromann Nicolaisen, Sandra Sif Gylfadottir, Troels Staehelin Jensen, Jens Steen Nielsen, Reimar Wernich Thomsen, Henning Andersen   +7 more
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The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?

Pharmaceuticals, 2021
Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system ...
Aurore Danigo, Amandine Rovini, Flavien Bessaguet, Hichem Bouchenaki, Amandine Bernard, Franck Sturtz, Sylvie Bourthoumieu, Alexis Desmoulière, Laurent Magy, Claire Demiot   +9 more
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Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice

Frontiers in Pharmacology, 2021
Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia.
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Laurent Magy, Claire Demiot   +10 more
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The Flavonoid Hesperidin Methyl Chalcone Targets Cytokines and Oxidative Stress to Reduce Diclofenac-Induced Acute Renal Injury: Contribution of the Nrf2 Redox-Sensitive Pathway

Antioxidants, 2022
Hesperidin is derived from citrus fruits among other plants. Hesperidin was methylated to increase its solubility, generating hesperidin methyl chalcone (HMC), an emerging flavonoid that possess anti-inflammatory and antioxidant properties.
Allan J. C. Bussmann, Tiago H. Zaninelli, Telma Saraiva-Santos, Victor Fattori, Carla F. S. Guazelli, Mariana M. Bertozzi, Ketlem C. Andrade, Camila R. Ferraz, Doumit Camilios-Neto, Antônio M. B. Casella, Rubia Casagrande, Sergio M. Borghi, Waldiceu A. Verri   +12 more
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Resolvin D5 (RvD5) Reduces Renal Damage Caused by LPS Endotoxemia in Female Mice

Molecules, 2022
In self-revolving gram-negative Escherichia coli infection, Resolvin D5 (RvD5) was found to enhance bacteria phagocytosis and reduce the production of inflammatory mediators, contributing to the resolution of infection. LPS (lipopolysaccharide) is a gram-
Renato D. R. Cardoso, Sandmary D. Chambo, Tiago H. Zaninelli, Beatriz H. S. Bianchini, Matheus Deroco Veloso da Silva, Mariana M. Bertozzi, Telma Saraiva-Santos, Anelise Franciosi, Geovana Martelossi-Cebinelli, Pamela E. Garcia-Miguel, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri   +12 more
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Sciatic neuropathy with preserved sensory nerve action potentials, a case series [PDF]

, 2020
Background: Sciatic neuropathy is differentiated from lumbosacral radiculopathy based on the finding of abnormal sensory nerve action potentials (SNAPs). Cases of sciatic neuropathy with intact SNAPS have not been well described. Methods: A retrospective
Li, Yuebing, Ritch, Matthew, Suhaib, Omer   +2 more
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Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions

Scientific Reports, 2021
Pyruvate functions as a key molecule in energy production and as an antioxidant. The efficacy of pyruvate supplementation in diabetic retinopathy and nephropathy has been shown in animal models; however, its significance in the functional maintenance of ...
Hideji Yako, Naoko Niimi, Ayako Kato, Shizuka Takaku, Yasuaki Tatsumi, Yasumasa Nishito, Koichi Kato, Kazunori Sango   +7 more
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Hesperidin Methyl Chalcone Reduces the Arthritis Caused by TiO₂ in Mice: Targeting Inflammation, Oxidative Stress, Cytokine Production, and Nociceptor Sensory Neuron Activation

Molecules, 2023
Arthroplasty is an orthopedic surgical procedure that replaces a dysfunctional joint by an orthopedic prosthesis, thereby restoring joint function. Upon the use of the joint prosthesis, a wearing process begins, which releases components such as titanium
Nayara A. Artero, Marília F. Manchope, Thacyana T. Carvalho, Telma Saraiva-Santos, Mariana M. Bertozzi, Jessica A. Carneiro, Anelise Franciosi, Amanda M. Dionisio, Tiago H. Zaninelli, Victor Fattori, Camila R. Ferraz, Maiara Piva, Sandra S. Mizokami, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A. Verri   +15 more
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Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1

Cells, 2023
Chikungunya virus is an arthropod-borne infectious agent that causes Chikungunya fever disease. About 90% of the infected patients experience intense polyarthralgia, affecting mainly the extremities but also the large joints such as the knees.
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri   +18 more
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